Evidence map›Paper›PMID 30019146›Full record

ArticleCancer immunology, immunotherapy : CII2018

Naturally produced type I IFNs enhance human myeloid dendritic cell maturation and IL-12p70 production and mediate elevated effector functions in innate and adaptive immune cells.

Annette E Sköld, Till S M Mathan, Jasper J P van Beek, Georgina Flórez-Grau, Michelle D van den Beukel, Simone P Sittig, Florian Wimmers, Ghaith Bakdash, Gerty Schreibelt, I Jolanda M de Vries

Open access · hybridAbstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  6. Article
  7. CD8Journal of translational medicine · 2024
    Review
  8. Review
  9. Guidelines for mouse and human DC generation.European journal of immunology · 2023
    Article
  10. Human CD34Cellular and molecular life sciences : CMLS · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Clinically applicable CD34Cancer immunology, immunotherapy : CII · 2021
    Article
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Annette E SköldDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0002-5309-8860
Till S M MathanDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Jasper J P van BeekDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Georgina Flórez-GrauDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Michelle D van den BeukelDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Simone P SittigDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Florian WimmersDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Ghaith BakdashDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
Gerty SchreibeltDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands.
I Jolanda M de VriesDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Geert Grooteplein 26/28, 6525 GA, Nijmegen, The Netherlands. Jolanda.deVries@radboudumc.nl.
Radboud University Nijmegen · NL

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 91814655Nederlandse Organisatie voor Wetenschappelijk Onderzoek 95103002Vetenskapsrådet 350-2012-6618
6 · The paper itself

Abstract

There has recently been a paradigm shift in the field of dendritic cell (DC)-based immunotherapy, where several clinical studies have confirmed the feasibility and advantageousness of using directly isolated human blood-derived DCs over in vitro differentiated subsets. There are two major DC subsets found in blood; plasmacytoid DCs (pDCs) and myeloid DCs (mDCs), and both have been tested clinically. CD1c

Indexed as

Antigens, CD1Coculture TechniquesDendritic CellsGlycoproteinsHumansImmunity, InnateInterferon-alphaInterferon alpha-2Interferon-gammaInterferon Type IInterleukin-12Lymphocyte ActivationMyeloid CellsQuinolinesRecombinant ProteinsT-LymphocytesAntigens, CD1CD1C protein, humanGlycoproteinsIFNG protein, humanInterferon-alphaInterferon alpha-2Interferon-gammaInterferon Type IInterleukin-12QuinolinesRecombinant ProteinsCell activationCytokinesDendritic cellsTumor immunityVaccination

Identifiers

PMID30019146
PMCPMC6132867
OpenAlexW2884709392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.