Evidence map›Paper›PMID 30019143›Full record

ArticleEuropean radiology2019

Diffusion and perfusion MRI quantification in ileal Crohn's disease.

Stefanie J Hectors, Sonja Gordic, Sahar Semaan, Octavia Bane, Robert Hirten, Xiaoyu Jia, Jean-Frederic Colombel, Bachir Taouli

Abstract read
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In one paragraph

Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  16. Magnetic resonance enterography and bowel ultrasonography in Saudi Arabian patients with Crohn's disease: A correlation study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Stefanie J HectorsTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sonja GordicTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sahar SemaanTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Octavia BaneTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert HirtenIBD Center, Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xiaoyu JiaDepartment of Population Health Science and Policy, Institute for Healthcare Delivery Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jean-Frederic ColombelIBD Center, Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bachir TaouliTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. bachir.taouli@mountsinai.org.
Icahn School of Medicine at Mount Sinai · USImaging Center · USUniversity Hospital of Zurich · CH

Funding

Advanced Software for MRI, PET, SPECT and CT Image AnalysisU24EB028980 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUSINEK, HENRY · 2019 to 2021
$1.2M
NIBIB NIH HHS U24 EB028980
6 · The paper itself

Abstract

objectivesTo quantify intravoxel incoherent motion (IVIM)-DWI and dynamic contrast-enhanced (DCE)-MRI parameters in normal and abnormal ileal segments in Crohn's disease (CD) patients and to assess the association of these parameters with clinical and MRI-based measurements of CD activity.

methodsIn this prospective study, 27 CD patients (M/F 18/9, mean age 42 years) underwent MR enterography, including IVIM-DWI and DCE-MRI. IVIM-DWI and DCE-MRI parameters were quantified in normal and abnormal small bowel segments, the latter identified by the presence of inflammatory changes. MRI parameter differences between normal and abnormal bowel were tested using Wilcoxon signed-rank tests. IVIM-DWI and DCE-MRI parameters were correlated with clinical data (C-reactive protein, Harvey-Bradshaw Index), conventional MRI parameters (wall thickness, length of involvement) and MRI activity scores (MaRIA, Clermont). Diagnostic performance of (combined) parameters for differentiation between normal and abnormal bowel was determined using ROC analysis.

resultsThe DCE-MRI parameters peak concentration C

conclusionsDCE-MRI and IVIM-DWI, particularly when used in combination, are promising for non-invasive evaluation of small bowel CD. KEY POINTS: • IVIM-DWI and DCE-MRI parameters were significantly different between normal and abnormal bowel segments in CD patients. • DCE-MRI parameters showed a significant association with wall thickness and MRI activity scores. • Combination of IVIM-DWI and DCE-MRI parameters led to the highest diagnostic performance for differentiation between normal and abnormal bowel segments, while ADC showed the highest diagnostic performance of individual parameters.

Indexed as

AdultContrast MediaCrohn DiseaseDiffusionDiffusion Magnetic Resonance ImagingFemaleHumansIleumMagnetic Resonance ImagingMaleMiddle AgedMotionPerfusionProspective StudiesROC CurveYoung AdultContrast MediaCrohn diseaseDiffusion magnetic resonance imagingPerfusion imaging

Identifiers

PMID30019143
OpenAlexW2883300849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.