Evidence map›Paper›PMID 30019137›Full record

ArticleMikrochimica acta2018

Aptamer based voltammetric biosensor for Mycobacterium tuberculosis antigen ESAT-6 using a nanohybrid material composed of reduced graphene oxide and a metal-organic framework.

Linlin Li, Yonghua Yuan, Yongjie Chen, Pu Zhang, Yan Bai, Lijuan Bai

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Biosensors; nanomaterial-based methods in diagnosing ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024
    Review
  5. Review
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  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Aptasensor for the Detection ofNanomaterials (Basel, Switzerland) · 2021
    Article
  13. Aptamers: An Emerging Tool for Diagnosis and Therapeutics in Tuberculosis.Frontiers in cellular and infection microbiology · 2021
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Linlin LiEngineering Technology Research Center for Pharmacodynamic Evaluation of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Yonghua YuanEngineering Technology Research Center for Pharmacodynamic Evaluation of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Yongjie ChenEngineering Technology Research Center for Pharmacodynamic Evaluation of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Pu ZhangEngineering Technology Research Center for Pharmacodynamic Evaluation of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Yan BaiEngineering Technology Research Center for Pharmacodynamic Evaluation of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Lijuan BaiEngineering Technology Research Center for Pharmacodynamic Evaluation of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, People's Republic of China. bailijua88@126.com.
Chongqing Medical University · CN

Funding

Fundamental and Advanced Research Projects of Chongqing City cstc2016jcyjA0275Funds for Young Science and Technology Talent Cultivation Plan of Chongqing City cstc2014kjrc-qnrc00004National Natural Science Foundation of China 81601856the Third Batch of Young Backbone Teachers Funding Program in Colleges and Universities of Chongqing City [2016] No. 53
6 · The paper itself

Abstract

The 6-kDa early secretory antigenic target referred to as ESAT-6 is a virulence factor secreted by Mycobacterium tuberculosis (MTB). This work describes a voltammetric aptasensor for ultrasensitive detection of ESAT-6. Reduced graphene oxide doped with metal-organic framework (MOF-rGO) was deposited on a glassy carbon electrode (GCE). This increases the immobilization of electroactive Toluidine Blue (TB) and facilitates the electron transfer from TB to the modified GCE. Platinum/gold core/shell (Pt@Au) nanoparticles were used to assemble thiolated ESAT-6 binding aptamer (EBA) on a modified electrode and to further amplify the response to TB. The modified GCE, typically operated at -0.36 V (vs. SCE), has a linear response in 1.0 × 10

Indexed as

Biosensing TechniquesAntigens, BacterialAptamers, NucleotideBacterial ProteinsCarbonElectrochemical TechniquesElectrodesGoldGraphiteHumansLimit of DetectionMetal NanoparticlesMetal-Organic FrameworksNanocompositesOxidation-ReductionParticle SizeAntigens, BacterialAptamers, NucleotideBacterial ProteinsCarbonESAT-6 protein, Mycobacterium tuberculosisGoldgraphene oxideGraphiteMetal-Organic FrameworksMycobacterium tuberculosis antigensPlatinumAptasensorCyclic voltammetryEffective surface areaElectrochemical detectionElectrochemical impedance spectroscopyPt@Au nanoparticlesSignal amplification

Identifiers

PMID30019137
OpenAlexW2883292142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.