ArticleCurrent microbiology2018
Contact-Dependent Growth Inhibition Proteins in Acinetobacter baylyi ADP1.
Article in Current microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Elongation Factor Tu Acts as a Chaperone to Activate an Antibacterial RNase Toxin.Molecular microbiology · 2026Article
- Pathogenicity and virulence ofVirulence · 2024Review
- Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition.PLoS genetics · 2024Article
- The antimicrobial peptide Temporin-L induces vesicle formation and reduces the virulence inBiochemistry and biophysics reports · 2024Article
- Assessing the Potential ofACS pharmacology & translational science · 2024Article
- Article
- Uncovering the Secretion Systems ofAntibiotics (Basel, Switzerland) · 2023Review
- The Glucocorticoid PYED-1 Disrupts Mature Biofilms ofAntibiotics (Basel, Switzerland) · 2021Article
- Inhibition of AdeB, AceI, and AmvA Efflux Pumps Restores Chlorhexidine and Benzalkonium Susceptibility inFrontiers in microbiology · 2021Article
- Contact-Dependent Growth Inhibition in Bacteria: Do Not Get Too Close!International journal of molecular sciences · 2020Review
- Article
- PYED-1 Inhibits Biofilm Formation and Disrupts the Preformed Biofilm ofAntibiotics (Basel, Switzerland) · 2020Article
- Steroid Derivatives as Potential Antimicrobial Agents AgainstMicroorganisms · 2020Article
- Antibacterial and Antivirulence Activity of Glucocorticoid PYED-1 againstAntibiotics (Basel, Switzerland) · 2020Article
- Capsule ProtectsFrontiers in microbiology · 2020Article
- Multidrug ResistantFrontiers in microbiology · 2020Article
- Role of Recipient Susceptibility Factors During Contact-Dependent Interbacterial Competition.Frontiers in microbiology · 2020Review
- The role of Acinetobacter baumannii response regulator BfmR in pellicle formation and competitiveness via contact-dependent inhibition system.BMC microbiology · 2019Article
- Diversity of Contact-Dependent Growth Inhibition Systems ofJournal of bacteriology · 2019Review
- The type VI secretion system protein AsaA in Acinetobacter baumannii is a periplasmic protein physically interacting with TssM and required for T6SS assembly.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial contact-dependent growth inhibition (CDI) systems are two-partner secretion systems in which toxic CdiA proteins are exported on the outer membrane by cognate transporter CdiB proteins. Upon binding to specific receptors, the C-terminal toxic (CT) domain, detached from CdiA, is delivered to neighbouring cells. Contacts inhibit the growth of not-self-bacteria, lacking immunity proteins co-expressed with CdiA, but promote cooperative behaviours in "self" bacteria, favouring the formation of biofilm structures. The Acinetobacter baylyi ADP1 strain features two CdiA, which differ significantly in size and have different CT domains. Homologous proteins sharing the same CT domains have been identified in A. baumannii. The growth inhibition property of the two A. baylyi CdiA proteins was supported by competition assays between wild-type cells and mutants lacking immunity genes. However, neither protein plays a role in biofilm formation or adherence to epithelial cells, as proved by assays carried out with knockout mutants. Inhibitory and stimulatory properties may be similarly uncoupled in A. baumannii proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.