Evidence map›Paper›PMID 30019089›Full record

ArticleEuropean journal of nutrition2019

Association between dietary total antioxidant capacity and hepatocellular ballooning in nonalcoholic steatohepatitis: a cross-sectional study.

Daiane Gonçalves de Oliveira, Fabiana de Faria Ghetti, Ana Paula Boroni Moreira, Helen Hermana Miranda Hermsdorff, Juliano Machado de Oliveira, Lincoln Eduardo Villela Vieira de Castro Ferreira

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Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daiane Gonçalves de OliveiraDepartamento de Nutrição, Universitary Hospital, School of Medicine, Federal University of Juiz de Fora, Bairro Martelos, s/n, CEP 36036-330, Juiz de Fora, Minas Gerais, Brazil. daianeg.oliver@yahoo.com.br.
Fabiana de Faria GhettiDepartamento de Nutrição, Universitary Hospital, School of Medicine, Federal University of Juiz de Fora, Bairro Martelos, s/n, CEP 36036-330, Juiz de Fora, Minas Gerais, Brazil.
Ana Paula Boroni MoreiraNutrition Department, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Helen Hermana Miranda HermsdorffNutrition and Health Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Juliano Machado de OliveiraDepartamento de Nutrição, Universitary Hospital, School of Medicine, Federal University of Juiz de Fora, Bairro Martelos, s/n, CEP 36036-330, Juiz de Fora, Minas Gerais, Brazil.
Lincoln Eduardo Villela Vieira de Castro FerreiraDepartamento de Nutrição, Universitary Hospital, School of Medicine, Federal University of Juiz de Fora, Bairro Martelos, s/n, CEP 36036-330, Juiz de Fora, Minas Gerais, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ 01522-15
6 · The paper itself

Abstract

purposeNonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, ballooning, and in some cases, fibrosis, which can progress to cirrhosis and carcinoma. The progression of NASH is closely related to oxidative stress. Dietary intake of antioxidants has been suggested in protection against oxidative damage and related clinical complications. Thus, we evaluated the potential association of dietary total antioxidant capacity (TAC) with disease severity in NASH patients, as well as with anthropometric and body composition markers and biochemical parameters.

methodsThirty-three outpatients with a mean age of 48.4 ± 1.9 years were evaluated. Dietary TAC was estimated from a quantitative food frequency questionnaire. NASH severity, determined by liver biopsy, lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters were assessed.

resultsNASH patients who had a higher dietary TAC had fewer ballooned hepatocytes compared to those with a lower TAC (p = 0.024). The patients with the highest dietary TAC had a reduction of approximately 20% in the risk of having many ballooned hepatocytes (OR 0.791; 95% CI 0.643-0.974; p = 0.027). There was no association of steatosis, lobular inflammation, and fibrosis with dietary TAC. The same occurred for lifestyle characteristics, occurrence of comorbidities, anthropometry, body composition, and biochemical parameters.

conclusionDietary TAC is higher in patients with lower hepatic injury (ballooning), suggesting a possible role of food intake naturally high in its antioxidant capacity in reducing free radical production and, consequently, oxidative stress.

Indexed as

AntioxidantsCross-Sectional StudiesDietFemaleHepatocytesHumansLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseOxidative StressSeverity of Illness IndexSurveys and QuestionnairesAntioxidantsDietary antioxidantsHepatocellular ballooningNonalcoholic steatohepatitisOxidative stressTotal antioxidant capacity

Identifiers

PMID30019089

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.