Evidence map›Paper›PMID 30019084›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis patients.

M Bernardes, C Durães, A Oliveira, M J Martins, R Lucas, L Costa, J G Pereira, I Ramos, J C Machado, F Simões-Ventura

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

M BernardesDepartment of Rheumatology, São João Hospital Centre, Porto, Portugal. mbernardes09@gmail.com.ORCID http://orcid.org/0000-0002-1849-5465
C DurãesIPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
A OliveiraDepartment of Nuclear Medicine, São João Hospital Centre, Porto, Portugal.
M J MartinsInstituto de Investigação e Inovação em Saúde (i3s), University of Porto, Porto, Portugal.
R LucasEPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.
L CostaDepartment of Rheumatology, São João Hospital Centre, Porto, Portugal.
J G PereiraDepartment of Nuclear Medicine, São João Hospital Centre, Porto, Portugal.
I RamosDepartment of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal.
J C MachadoIPATIMUP - Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal.
F Simões-VenturaFaculty of Medicine, University of Porto, Porto, Portugal.
Universidade do Porto · PTHospital de São João · PT

Funding

Associação Nacional de Reumatologia not aplicable
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is characterized by increased bone resorption and impaired bone formation. Osteoblast function is regulated by the canonical LRP5/Wnt/β-catenin pathway. Bone mineral density and RA joint destruction are partially inherited. In line with this, we found significant associations between LRP5 SNPs (p.A1330V, p.N740N, p.V667M) and RA radiographic damage severity.

introductionIncreased bone resorption and impaired bone formation characterize rheumatoid arthritis (RA). Canonical Wnt/β-catenin pathway, signalled by lipoprotein receptor-related protein-5 (LRP5), regulates osteoblast function. Since bone mineral density (BMD) and RA joint destruction are partially inherited, we studied their association with LRP5 single nucleotide polymorphisms (SNPs).

methodsClinical data and peripheral blood for biomarkers assessment and LRP5 genotyping were collected from 208 RA patients. Hands and feet X-rays were scored [modified Sharp/van der Heijde Score (SHS), joint space narrowing (JSN), and erosion scores]. Lumbar spine, total left proximal femur, and left hand BMD were assessed by dual-energy X-ray absorptiometry (DXA).

resultsTT genotypes for p.A1330V and p.N740N LRP5 SNPs associated with total SHS, erosion score, and hands erosion score; the same for p.A1330V with feet JSN score and p.N740N with hands total score. AG genotype for p.V667M associated with sclerostin and hands JSN score. Femoral BMD associated with TC genotype for p.N740N. Multiple test correction precluded a few of these associations. Among V667M-N740N-A1330V haplotypes: GTT associated with higher feet JSN score (OR = 3.80; p = 0.016) and ATT with higher JSN score (OR = 4.60; p = 0.032), hands total score (OR = 5.65; p = 0.022), and total SHS (OR = 6.74; p = 0.024).

conclusionSignificant associations between LRP5 SNPs (p.A1330V, p.N740N, and p.V667M) and the severity of radiographic damage reinforce the evidence of bone destruction heritability in RA.

Indexed as

Polymorphism, Single NucleotideAbsorptiometry, PhotonAgedArthritis, RheumatoidBone DensityBone ResorptionFemaleFemurHand BonesHumansLow Density Lipoprotein Receptor-Related Protein-5Lumbar VertebraeMaleMiddle AgedRadiographyLow Density Lipoprotein Receptor-Related Protein-5LRP5 protein, humanBone mineral densityDXALRP5Modified Sharp/van der Heijde scoreRheumatoid arthritisSclerostin

Identifiers

PMID30019084
OpenAlexW2883388682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.