Evidence map›Paper›PMID 30019022›Full record

ArticleJournal of the Endocrine Society2018

Elevated Levels of Organochlorine Pesticides in South Asian Immigrants Are Associated With an Increased Risk of Diabetes.

Sarah I Daniels, John C Chambers, Sylvia S Sanchez, Michele A La Merrill, Alan E Hubbard, Anthony Macherone, Matthew McMullin, Luoping Zhang, Paul Elliott, Martyn T Smith and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  7. Persistent organic pollutants and β-cell toxicity: a comprehensive review.American journal of physiology. Endocrinology and metabolism · 2022
    Review
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  13. Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Sarah I DanielsSuperfund Research Center, School of Public Health, University of California, Berkeley, California.
John C ChambersLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Sylvia S SanchezSuperfund Research Center, School of Public Health, University of California, Berkeley, California.
Michele A La MerrillDepartment of Environmental Toxicology, University of California, Davis, California.
Alan E HubbardSuperfund Research Center, School of Public Health, University of California, Berkeley, California.
Anthony MacheroneAgilent Technologies, Inc., Santa Clara, California.
Matthew McMullinNMS Laboratories, Willow Grove, Pennsylvania.
Luoping ZhangSuperfund Research Center, School of Public Health, University of California, Berkeley, California.
Paul ElliottDepartment of Epidemiology and Biostatistics, Imperial College, London, United Kingdom.
Martyn T SmithSuperfund Research Center, School of Public Health, University of California, Berkeley, California.
Jaspal KoonerDepartment of Cardiology, Ealing Hospital, Middlesex, United Kingdom.
University of California, Berkeley · USImperial College London · GBEvaporated Coatings (United States) · USJohns Hopkins University · USMRC Centre for Environment and HealthUniversity of California, Davis · US

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MORELLO-FROSCH, RACHEL ADELE · 1987 to 2025
$74.6M
Perinatal DDT causes insulin resistance in mice through impaired thermogenesisR01ES024946 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LA MERRILL, MICHELE A · 2016 to 2020
$1.9M
Medical Research Council G0601966Medical Research Council G0700931Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1NIEHS NIH HHS P42 ES004705NIEHS NIH HHS R01 ES024946Wellcome Trust
6 · The paper itself

Abstract

objectiveRates of diabetes mellitus are higher in South Asians than in other populations and persist after migration. One unexplored cause may be higher exposure to persistent organic pollutants associated with diabetes in other populations. We compared organochlorine (OC) pesticide concentrations in South Asian immigrants and European whites to determine whether the disease was positively associated with OC pesticides in South Asians. RESEARCH DESIGN AND

methodsSouth Asians of Tamil or Telugu descent (n = 120) and European whites (n = 72) were recruited into the London Life Sciences Population Study cohort. Blood samples as well as biometric, clinical, and survey data were collected. Plasma levels of

resultsTamils had approximately threefold to ninefold higher levels of OC pesticides, and Telugus had ninefold to 30-fold higher levels compared with European whites. The odds of exposure to

conclusionsSouth Asian immigrants have a higher body burden of OC pesticides than European whites. Diabetes mellitus is associated with higher

Indexed as

dichlorodiphenyldichloroethylene (DDE)dichlorodiphenyltrichloroethane (DDT)hexachlorohexaneIndiapersistent organic pollutantsSri Lanka

Identifiers

PMID30019022
PMCPMC6041775
OpenAlexW2804432044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.