Evidence map›Paper›PMID 30018938›Full record

ArticleJournal of exercise rehabilitation2018

Synaptophysin and caspase-3 expression on lumbar segments of spinal cord after sensorimotor restriction during early postnatal period and treadmill training.

Felipe Stigger, Silvia Barbosa, Marília Rossato Marques, Ethiane Segabinazi, Otávio Américo Augustin, Matilde Achaval, Simone Marcuzzo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of exercise rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Anti-Apoptotic Effect of Chrysophanol Isolated fromInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Felipe StiggerDepartment of Physiotherapy, Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil.
Silvia BarbosaLaboratory of Comparative Histophysiology, Department of Morphological Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Marília Rossato MarquesPostgraduation Program of Neurosciences, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Ethiane SegabinaziPostgraduation Program of Neurosciences, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Otávio Américo AugustinLaboratory of Comparative Histophysiology, Department of Morphological Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Matilde AchavalPostgraduation Program of Neurosciences, Department of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Simone MarcuzzoPostgraduation Program of Neurosciences, Department of Morphological Sciences, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the current study was to investigate whether locomotor stimulation training could have beneficial effects on spinal cord plasticity consequent to sensorimotor restriction (SR). Male Wistar rats were exposed to SR from postnatal day 2 (P2) to P28. Control and experimental rats underwent locomotor stimulation training in a treadmill from P31 to P52. The intensity of the synaptophysin and caspase-3 immunoreaction was determined on ventral horn of spinal cord. The synaptophysin immunoreactivity was lower in the ventral horn of sensorimotor restricted rats compared to controls animals and was accompanied by an increased caspase-3 immunoreactivity. Those alterations were reversed at the end of the training period. Our results suggest that immobility affects the normal developmental process that spinal cord undergoes in early postnatal life influencing both pro-apoptotic and synapse markers. Also, we demonstrated that this phenomenon was reversed by 3 weeks of treadmill training.

Indexed as

ApoptosisDevelopmental disuseSpinal cord plasticityTreadmill walking training

Identifiers

PMID30018938
PMCPMC6028203
OpenAlexW2810314554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.