Evidence map›Paper›PMID 30018800›Full record

ArticleRMD open2018

Non-classical human leucocyte antigens in ankylosing spondylitis: possible association with HLA-E and HLA-F.

Margarida Rodrigues Santos, Ana Rita Couto, Iris Foroni, Bruno Filipe Bettencourt, Zhixiu Li, Raquel Meneses, Lawrie Wheeler, Joaquim Pereira, Fernando Pimentel-Santos, João Eurico Fonseca and 5 more

Open access · goldAbstract read
In one paragraph

Article in RMD open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Dimorphism of HLA-E and its Disease Association.International journal of molecular sciences · 2019
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Margarida Rodrigues SantosServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Ana Rita CoutoServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Iris ForoniServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Bruno Filipe BettencourtServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Zhixiu LiInstitute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Australia.
Raquel MenesesServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Lawrie WheelerInstitute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Australia.
Joaquim PereiraServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Fernando Pimentel-SantosCEDOC, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
João Eurico FonsecaIMM, Universidade de Lisboa, Lisboa, Portugal.
Helena AlvesCentro de Histocompatibilidade do Norte, Instituto Português do Sangue e da Transplantação, Porto, Portugal.
António MartinhoCentro de Sangue e Transplantação de Coimbra, Instituto Português do Sangue e da Transplantação, Coimbra, Portugal.
Manuela LimaFaculdade de Ciências e Tecnologia, Universidade dos Açores, Ponta Delgada, Portugal.
Matthew A BrownInstitute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Brisbane, Australia.
Jácome Bruges-ArmasServiço Especializado de Epidemiologia e Biologia Molecular, Hospital de Santo Espirito da Ilha Terceira, EPER, Angra do Heroismo, Portugal.
Hospital de Santo Espirito de Angra do Heroísmo · PTQueensland University of Technology · AUInstituto Português de Oncologia de Coimbra Francisco Gentil · PTIPO Porto · PTTranslational Research Institute · AUUniversidade dos Açores · PTUniversidade Nova de Lisboa · PTUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAnkylosing spondylitis (AS) is the most prevalent form of spondyloarthritis, with a known genetic association with the HLA-B27 molecule. The aim of this study was to assess the contribution of the HLA-G, HLA-E and HLA-F to AS susceptibility/protection in Portuguese patients with HLA-B27 AS and HLA-B27 unaffected controls.

methodsHigh-resolution typing of

resultsIn the Portuguese population, no significant differences were found in

conclusionOur results reveal suggestive AS protective and susceptibility effects from both

Indexed as

ankylosing spondylitisautoimmune diseasesgene polymorphismHLAinflammationspondyloarthritis

Identifiers

PMID30018800
PMCPMC6045739
OpenAlexW2810846616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.