ArticleVeterinary record open2018
Analgesic effects of intravenous flunixin and intrafunicular lidocaine or their combination for castration of lambs.
Article in Veterinary record open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- An Exploration of Analgesia Options for Australian Sheep.Animals : an open access journal from MDPI · 2024Review
- The Clinical Effect of Xylazine Premedication in Water Buffalo Calves (Animals : an open access journal from MDPI · 2021Article
- Analgesic Effect of Butorphanol during Castration in Donkeys under Total Intravenous Anaesthesia.Animals : an open access journal from MDPI · 2021Article
- Evaluation of Electroencephalography, Behaviour and Eye Temperature in Response to Surgical Castration in Sheep.Animals : an open access journal from MDPI · 2021Article
- Evaluation of the pharmacokinetics and efficacy of transdermal flunixin for pain mitigation following castration in goats.Translational animal science · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyse the effectiveness of intrafunicular lidocaine and intravenous flunixin for reducing pain and signs of stress in lambs undergoing surgical castration.
designRandomised controlled trial.
settingOne university teaching hospital in Italy.
participants30 healthy male lambs, 9-12 weeks old.
interventionAllocation to five groups: a control group (C), undergoing general anaesthesia but not castration; a surgery group (S), undergoing orchiectomy without analgesic treatment; a surgery-lidocaine group (SL), undergoing orchiectomy and receiving intrafunicular 2 per cent lidocaine solution; a surgery-flunixin group (SF), undergoing orchiectomy and receiving intravenous flunixin; a surgery-flunixin-lidocaine group (SFL), undergoing orchiectomy and receiving both intrafunicular lidocaine and intravenous flunixin.
main outcome measuresNociception and stress were assessed through intraoperative indicators, serum cortisol concentration, glycaemia, behaviour, immune response and clinical evaluation of the heart rate (HR), respiratory rate and rectal temperature after surgery.
resultsGroups S and SL showed increased values of intraoperative HR, mean arterial pressure and postoperative cortisol concentration. In group SFL, cortisol values were similar to those of group C. No other difference could be detected.
conclusionsThe combination of intravenous flunixin and intrafunicular lidocaine reduced the pain and discomfort of lambs castrated under general anaesthesia. Intrafunicular lidocaine alone did not prevent pain or discomfort associated with castration. TRIAL REGISTRATION NUMBER: 30/2012/CEISA/COM.
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Registered trials
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