Evidence map›Paper›PMID 30018729›Full record

ArticleAmerican journal of translational research2018

The use of allogenic adipose-derived stem cells in combination with platelet-rich fibrin for the treatment of cartilage defects in rabbit ear.

Fangfang Xu, Yong Yang, Tao Yang, Taiqiang Dai, Xiaoxi Shao, Haiyan Xu, Ran An, Yanpu Liu, Bin Liu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Article
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  6. Short histological kaleidoscope - recent findings in histology. Part V. About tendons, ligaments, and cartilages.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Fangfang XuState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Yong YangState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Tao YangState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Taiqiang DaiState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Xiaoxi ShaoState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Haiyan XuState Key Laboratory of Military Stomatology, Laboratory Animal Center, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Ran AnState Key Laboratory of Military Stomatology, Laboratory Animal Center, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Yanpu LiuState Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Bin LiuState Key Laboratory of Military Stomatology, Laboratory Animal Center, School of Stomatology, The Fourth Military Medical University Xi'an 710032, P. R. China.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study aims to assess the efficacy of allogenic adipose-derived stem cells (ADSCs) together with platelet-rich fibrin (PRF) for the treatment of rabbit ear cartilage defects. For this study, 12 New Zealand white rabbits were randomly allocated into 4 groups. Two full-thickness cartilage defects were created in the rabbit ears. Group 1 was left untreated; Group 2 was treated with allogenic ADSCs, Group 3 was treated with PRF; Group 4 was treated with allogenic ADSCs and PRF. Macroscopic observation, hematoxylin and eosin staining, and Alcian blue staining after 3 months suggested that the allogenic ADSCs/PRF significantly accelerated cartilage regeneration compared to other groups and this was associated with increased expression of collagen II relative to the other groups. Expression of genes associated with immune response such as cluster of differentiation 4 and 8 (CD4, CD8), and interleukin 2 and 4 (IL-2, IL-4) displayed no significant statistical difference compared to Group 1. In conclusion, these results suggest that allogenic ADSCs in combination with PRF can accelerate regeneration in full-thickness cartilage defects in the rabbit ear model without causing a significant immune response. The results suggest that allogenic ADSCs with PRF could successfully be used for cartilage regeneration.

Indexed as

Adipose-derived stem cellscartilage defectsimmune responseplatelet-rich fibrin

Identifiers

PMID30018729
PMCPMC6038059
OpenAlexW2998336535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.