Evidence map›Paper›PMID 30018618›Full record

ReviewFrontiers in immunology2018

Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment.

Daria S Chulpanova, Kristina V Kitaeva, Victoria James, Albert A Rizvanov, Valeriya V Solovyeva

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Daria S ChulpanovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Kristina V KitaevaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Victoria JamesSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, United Kingdom.
Albert A RizvanovInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Valeriya V SolovyevaInstitute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Kazan Federal University · RUUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment, such as endothelial cells, tumor-associated fibroblasts, pericytes, and immune system cells. The EVs carry the cargo of parental cells formed of proteins and nucleic acids, which can convey cell-to-cell communication influencing the maintenance and spread of the malignant neoplasm, for example, promoting angiogenesis, tumor cell invasion, and immune escape. However, EVs can also suppress tumor progression, either by the direct influence of the protein and nucleic acid cargo of the EVs or

Indexed as

cancer therapyextracellular vesiclesimmune cellsstromal cellstumor cellstumor microenvironmentvaccination

Identifiers

PMID30018618
PMCPMC6037714
OpenAlexW2811498745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.