ReviewFrontiers in microbiology2018
On the Natural History of Flavin-Based Electron Bifurcation.
Review in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- pK Values of the Cofactor Tune the Redox Regime of Flavoenzymes.Life (Basel, Switzerland) · 2026Article
- Article
- Lessons, connections, hypotheses and predictions from protein film electrochemistry.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Review
- An electron-bifurcating "plug" to a protein nanowire in tungsten-dependent aldehyde detoxification.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories.Cell stress · 2025Review
- Rethinking life and predicting its origin.Theory in biosciences = Theorie in den Biowissenschaften · 2024Article
- Structures and Electron Transport Paths in the Four Families of Flavin-Based Electron Bifurcation Enzymes.Sub-cellular biochemistry · 2024Review
- Accumulation of Four Electrons on a Terphenyl (Bis)disulfide.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Machine Learning for Efficient Prediction of Protein Redox Potential: The Flavoproteins Case.Journal of chemical information and modeling · 2022Article
- Article
- An uncharacteristically low-potential flavin governs the energy landscape of electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Structural Features of CytochromeInternational journal of molecular sciences · 2021Review
- Iron-sulfur flavoenzymes: the added value of making the most ancient redox cofactors and the versatile flavins work together.Open biology · 2021Article
- Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein.The Journal of biological chemistry · 2020Article
- Universal free-energy landscape produces efficient and reversible electron bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Electrochemical Characterization of a Complex FeFe Hydrogenase, the Electron-Bifurcating Hnd FromFrontiers in chemistry · 2020Article
- The Beta Subunit of Non-bifurcating NADH-Dependent [FeFe]-Hydrogenases Differs From Those of Multimeric Electron-Bifurcating [FeFe]-Hydrogenases.Frontiers in microbiology · 2020Article
- Prospecting for life.Interface focus · 2019Article
- Fougerite: the not so simple progenitor of the first cells.Interface focus · 2019Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electron bifurcation is here described as a special case of the continuum of electron transfer reactions accessible to two-electron redox compounds with redox cooperativity. We argue that electron bifurcation is foremost an electrochemical phenomenon based on (a) strongly inverted redox potentials of the individual redox transitions, (b) a high endergonicity of the first redox transition, and (c) an escapement-type mechanism rendering completion of the first electron transfer contingent on occurrence of the second one. This mechanism is proposed to govern both the traditional quinone-based and the newly discovered flavin-based versions of electron bifurcation. Conserved and variable aspects of the spatial arrangement of electron transfer partners in flavoenzymes are assayed by comparing the presently available 3D structures. A wide sample of flavoenzymes is analyzed with respect to conserved structural modules and three major structural groups are identified which serve as basic frames for the evolutionary construction of a plethora of flavin-containing redox enzymes. We argue that flavin-based and other types of electron bifurcation are of primordial importance to free energy conversion, the quintessential foundation of life, and discuss a plausible evolutionary ancestry of the mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.