Evidence map›Paper›PMID 30018269›Full record

ArticleMolecules (Basel, Switzerland)2018

High-Resolution PTP1B Inhibition Profiling Combined with HPLC-HRMS-SPE-NMR for Identification of PTP1B Inhibitors from

Rita de Cássia Lemos Lima, Kenneth T Kongstad, Lucília Kato, Marcos José das Silva, Henrik Franzyk, Dan Staerk

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Three New Triterpene Glycosides from the Roots ofMolecules (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Review
  7. The GenusMolecules (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rita de Cássia Lemos LimaDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. ritalemosrm@gmail.com.ORCID 0000-0002-7284-0231
Kenneth T KongstadDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. kenneth.kongstad@sund.ku.dk.ORCID 0000-0003-4487-7886
Lucília KatoInstituto de Química, Universidade Federal de Goiás, Goiânia 70040-010, Brazil. luciliakato@gmail.com.
Marcos José das SilvaInstituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia 70040-010, Brazil. marcos_agrorural@hotmail.com.
Henrik FranzykDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. henrik.franzyk@sund.ku.dk.ORCID 0000-0002-2822-1927
Dan StaerkDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark. ds@sund.ku.dk.ORCID 0000-0003-0074-298X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein tyrosine phosphatase 1B (PTP1B) is an intracellular enzyme responsible for deactivation of the insulin receptor, and consequently acts as a negative regulator of insulin signal transduction. In recent years, PTP1B has become an important target for controlling insulin resistance and type 2 diabetes. In the present study, the ethyl acetate extract of leaves of

Indexed as

Phosphodiesterase InhibitorsChromatography, High Pressure LiquidHumansMelastomataceaeNuclear Magnetic Resonance, BiomolecularPlant LeavesProtein Tyrosine Phosphatase, Non-Receptor Type 1Phosphodiesterase InhibitorsProtein Tyrosine Phosphatase, Non-Receptor Type 1PTPN1 protein, humanHPLC-HRMS-SPE-NMRMiconia albicansPTP1Btype 2 diabetes

Identifiers

PMID30018269
PMCPMC6100288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.