Evidence map›Paper›PMID 30018188›Full record

ReviewInternational journal of molecular sciences2018

The Nefarious Nexus of Noncoding RNAs in Cancer.

Eleni Anastasiadou, Alberto Faggioni, Pankaj Trivedi, Frank J Slack

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 68 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
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  7. Article
  8. The essential roles of lncRNAs/PI3K/AKT axis in gastrointestinal tumors.Frontiers in cell and developmental biology · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Expression Profile Analysis of Circular RNAs in Leishmaniasis.Tropical medicine and infectious disease · 2022
    Article
  17. Article
  18. Article
  19. circ_0000567/miR-421/Journal of Cancer · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Eleni AnastasiadouHMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Eanasta1@bidmc.harvard.edu.ORCID 0000-0003-0212-6734
Alberto FaggioniDepartment of Experimental Medicine, La Sapienza University, Viale Regina Elena 324, 0161 Rome, Italy. alberto.faggioni@uniroma1.it.
Pankaj TrivediDepartment of Experimental Medicine, La Sapienza University, Viale Regina Elena 324, 0161 Rome, Italy. pankaj.trivedi@uniroma1.it.
Frank J SlackHMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. fslack@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USSapienza University of Rome · IT

Funding

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung CancerP50CA196530 · NCI · YALE UNIVERSITY · PI Kurt A Schalper · 2015 to 2026
$31.1M
NCI NIH HHS P50 CA196530
6 · The paper itself

Abstract

The past decade has witnessed enormous progress, and has seen the noncoding RNAs (ncRNAs) turn from the so-called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts. Many ncRNAs interact with each other and are part of networks that influence the cell transcriptome and proteome and consequently the outcome of biological processes. The regulatory circuits controlled by ncRNAs have become increasingly more relevant in cancer. Further understanding of these complex network interactions and how ncRNAs are regulated, is paving the way for the identification of better therapeutic strategies in cancer.

Indexed as

Gene Expression Regulation, Neoplastic3' Untranslated RegionsGene Regulatory NetworksHumansMicroRNAsModels, GeneticNeoplasmsProto-Oncogene ProteinsRNARNA, CircularRNA, Long Noncoding3' Untranslated RegionsMicroRNAsProto-Oncogene ProteinsRNARNA, CircularRNA, Long Noncodingcancer biomarkerscircRNAlncRNAmiRNAncRNA network in cancernoncoding RNARNA aided cancer therapy

Identifiers

PMID30018188
PMCPMC6073630
OpenAlexW2793359584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.