Evidence map›Paper›PMID 30018106›Full record

ArticlemBio2018

A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa.

Disha Srivastava, Jin Seo, Binayak Rimal, Sung Joon Kim, Stephanie Zhen, Andrew J Darwin

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Peptidoglycan remodeling improves salt resilience ofApplied and environmental microbiology · 2026
    Article
  2. A conserved hub protein required for peptidoglycan remodeling and cell division inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Control of theJournal of bacteriology · 2025
    Article
  5. Article
  6. A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Tail-specific protease is an essentialInfection and immunity · 2024
    Article
  8. Journal of bacteriology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
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  17. Article
  18. Article
  19. Phenotypic and genotypic characterisation ofCurrent research in food science · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Disha SrivastavaDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Jin SeoDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Binayak RimalInstitute of Biomedical Studies, Baylor University, Waco, Texas, USA.
Sung Joon KimDepartment of Chemistry and Biochemistry, Baylor University, Waco, Texas, USA.ORCID 0000-0002-2007-6606
Stephanie ZhenDepartment of Microbiology, New York University School of Medicine, New York, New York, USA.
Andrew J DarwinDepartment of Microbiology, New York University School of Medicine, New York, New York, USA andrew.darwin@med.nyu.edu.ORCID 0000-0002-7751-1293
New York University · USBaylor University · US

Funding

C-terminal proteolysis in the Pseudomonas aeruginosa cell envelopeR01AI136901 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DARWIN, ANDREW J. · 2018 to 2023
$3.1M
GLYCOPEPTIDE COMPLEXES WITH BACTERIAL CELL WALLS BY REDORR01GM116130 · NIGMS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2015 to 2018
$1.2M
The Pseudomonas aeruginosa protease CtpA and type 3 secretionR21AI117131 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DARWIN, ANDREW J. · 2015 to 2016
$466k
NIAID NIH HHS R01 AI136901NIAID NIH HHS R21 AI117131NIGMS NIH HHS R01 GM116130
6 · The paper itself

Abstract

Carboxy-terminal processing proteases (CTPs) occur in all three domains of life. In bacteria, some of them have been associated with virulence. However, the precise roles of bacterial CTPs are poorly understood, and few direct proteolytic substrates have been identified. One bacterial CTP is the CtpA protease of

Indexed as

Bacterial ProteinsCell WallEndopeptidasesModels, BiologicalN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanProtein BindingProteolysisPseudomonas aeruginosaType III Secretion SystemsBacterial ProteinsC-terminal processing peptidaseEndopeptidasesN-Acetylmuramoyl-L-alanine AmidasePeptidoglycanType III Secretion Systemscell envelopecell wallpeptidoglycan hydrolasesproteasesPseudomonas aeruginosa

Identifiers

PMID30018106
PMCPMC6050968
OpenAlexW2950672607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.