Evidence map›Paper›PMID 30017863›Full record

ArticleDevelopmental and comparative immunology2018

Clip domain prophenoloxidase activating protease is required for Ostrinia furnacalis Guenée to defend against bacterial infection.

Congjing Feng, Ya Zhao, Kangkang Chen, Huifeng Zhai, Zhenying Wang, Haobo Jiang, Yingjuan Wang, Libao Wang, Yiqiang Zhang, Tai Tang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental and comparative immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Congjing FengDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China. Electronic address: fengcj@yzu.edu.cn.
Ya ZhaoDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Kangkang ChenDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Huifeng ZhaiDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Zhenying WangState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Haobo JiangDepartment of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA.
Yingjuan WangDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Libao WangDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Yiqiang ZhangDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Tai TangDepartment of Plant Protection, College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Yangzhou University · CNInstitute of Plant Protection · CNOklahoma State University · US

Funding

Initiation and Regulation of Prophenoloxidase ActivationR01GM058634 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI JIANG, HAOBO · 1999 to 2022
$4.0M
Activation and catalytic mechanisms of mosquito phenoloxidasesR21AI139998 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI JIANG, HAOBO · 2018 to 2019
$402k
Prophenoloxidases of Anopheles gambiaeR21AI112662 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI JIANG, HAOBO · 2014 to 2015
$381k
NIAID NIH HHS R21 AI112662NIAID NIH HHS R21 AI139998NIGMS NIH HHS R01 GM058634
6 · The paper itself

Abstract

The prophenoloxidase (PPO) activating system in insects plays an important role in defense against microbial invasion. In this paper, we identified a PPO activating protease (designated OfPAP) containing a 1203 bp open reading frame encoding a 400-residue protein composed of two clip domains and a C-terminal serine protease domain from Ostrinia furnacalis. SignalP analysis revealed a putative signal peptide of 18 residues. The mature OfPAP was predicted to be 382 residues long with a calculated M

Indexed as

Amino Acid SequenceAnimalsBase SequenceBinding SitesCatechol OxidaseDisease ResistanceEnzyme ActivationEnzyme PrecursorsEscherichia coliGene Expression Regulation, EnzymologicHemocytesHemolymphInsect ProteinsLarvaMothsPhylogenyCatechol OxidaseEnzyme PrecursorsInsect Proteinspro-phenoloxidaseBacterial challengeHemolymph proteinInsect immunityMelanizationRNA interference

Identifiers

PMID30017863
PMCPMC6093219
OpenAlexW2810381493

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.