ArticleEBioMedicine2018
Genetic variants in the CNTNAP2 gene are associated with gender differences among dyslexic children in China.
Article in EBioMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 42 citations in OpenAlex.
- Sex-stratified genetic regulators of cytokine production in the Dutch and Tanzanian populations.HGG advances · 2026Article
- Drivers of systemic male-female allele frequency divergence in humans.bioRxiv : the preprint server for biology · 2026Article
- Development and Validity of the Adult Reading History Questionnaire (ARHQ) for Chinese.Dyslexia (Chichester, England) · 2025Article
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- Sex Differences in Low-Level Multisensory Integration in Developmental Dyslexia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity.BMC medical genomics · 2023Article
- Sexual dimorphism in the social behaviour of Cntnap2-null mice correlates with disrupted synaptic connectivity and increased microglial activity in the anterior cingulate cortex.Communications biology · 2023Article
- Exploring Genetic and Neural Risk of Specific Reading Disability within a Nuclear Twin Family Case Study: A Translational Clinical Application.Journal of personalized medicine · 2023Article
- Construct validity of international literacy measures: implications for dyslexia across cultures.Journal of cultural cognitive science · 2022Article
- The Prevalence and Associated Risk Factors of Children With Reading Disabilities in a Multiethnic City: A Cross-Sectional Study.Frontiers in pediatrics · 2022Article
- Study of rare genetic variants inMeta gene · 2021Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- Neuroimaging genetic associations betweenJournal of clinical and experimental neuropsychology · 2021Article
- GABAFrontiers in integrative neuroscience · 2021Article
- The Prevalence of Dyslexia in Primary School Children and Their Chinese Literacy Assessment in Shantou, China.International journal of environmental research and public health · 2020Article
- Identifying interactive biological pathways associated with reading disability.Brain and behavior · 2020Article
- Sex differences in gene expression patterns associated with theF1000Research · 2019Article
- Neurobiological Sex Differences in Developmental Dyslexia.Frontiers in psychology · 2018Article
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well known that males have a higher prevalence of developmental dyslexia (DD) than females. Although the mechanism underlying this gender difference remains unknown, the contactin-associated protein-like 2 (CNTNAP2) gene, which shows sex-specific patterns in some neurodevelopmental disorders, has attracted extensive attention. This study aimed to explore whether CNTNAP2 shows a sex-specific association with DD in a Chinese population.
methodsUsing genomic DNA samples of 726 students [372 cases (282 male, 90 female), 354 controls (267 male, 87 female)], we genotyped five SNPs of CNTNAP2. Gender-stratified logistic regression models were used to determine the relationships between the CNTNAP2 variants and DD.
findingsAfter adjustment for the false discovery rate (FDR), two SNPs (rs3779031, rs987456) of CNTNAP2 were associated with DD risk in females but not in males. Female participants carrying the rs3779031 G allele had a lower risk of DD than those with the A genotype [GG vs AA: OR (95%CI) = 0.281 (0.097-0.814)]. The rs987456 CC genotype was associated with a decreased risk of DD in females [CC vs AA+CA: OR (95%CI) = 0.222 (0.078-0.628)]. Furthermore, the interaction between CNTNAP2 (rs987456) and environmental factors (scheduled reading time) played a protective role in females [OR (95%CI) = 0.431 (0.188-0.987)].
interpretationWe performed a genetic association study on CNTNAP2 variants and DD. The sex specificity of CNTNAP2 in DD, along with the gene-environment interaction may help us to understand gender differences in DD.
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