ArticleJournal of the American Medical Directors Association2019
Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study.
Article in Journal of the American Medical Directors Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Epidemiological and clinical evidence on blood pressure management for the prevention of dementia: striving for a healthy 100-year life.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Article
- Differential effects of cognitive training and aerobic exercise on regional gray matter volume and inter-regional covariance in community-dwelling older adults.Scientific reports · 2026Article
- Vascular cognitive impairment in China: Epidemiology, risk factors, healthcare system, management challenges, therapeutic modalities, and prevention strategies.Cerebral circulation - cognition and behavior · 2026Review
- Association between hypertension and dementia risk in low- and middle-income countries: A systematic review.JAR life · 2025Review
- Article
- Association between blood pressure and dementia in older adults: a cross-sectional study from China.Frontiers in aging neuroscience · 2024Article
- [Risk factors associated with cognitive impairment in aged: Cross-sectional study].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Associations between trajectories of cardiovascular risk factor change and cognitive impairment in Chinese elderly: A nationwide cohort study.Frontiers in aging neuroscience · 2023Article
- Trends and disparities in sleep quality and duration in older adults in China from 2008 to 2018: A national observational study.Frontiers in public health · 2023Observational
- Gender-and age-specific associations of sleep duration and quality with cognitive impairment in community-dwelling older adults in Anhui Province, China.Frontiers in public health · 2023Article
- Systolic Blood Pressure and Mortality in Community-Dwelling Older Adults: The Role of Frailty.The journal of nutrition, health & aging · 2022Article
- The interaction and pathogenesis between cognitive impairment and common cardiovascular diseases in the elderly.Therapeutic advances in chronic disease · 2022Review
- Hearing Impairment With Cognitive Decline Increases All-Cause Mortality Risk in Chinese Adults Aged 65 Years or Older: A Population-Based Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- Associations of changes in late-life blood pressure with cognitive impairment among older population in China.BMC geriatrics · 2021Article
- Tourism experiences and the lower risk of mortality in the Chinese elderly: a national cohort study.BMC public health · 2021Article
- Associations of Vascular Risk Factors,Frontiers in psychiatry · 2021Article
- High Blood Uric Acid Is Associated With Reduced Risks of Mild Cognitive Impairment Among Older Adults in China: A 9-Year Prospective Cohort Study.Frontiers in aging neuroscience · 2021Article
- Specific Leisure Activities and Cognitive Functions Among the Oldest-Old: The Chinese Longitudinal Healthy Longevity Survey.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.BMC geriatrics · 2020Article
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Authors and funding
12 authors.
Funding
Abstract
objectivesTo investigate the association between late-life blood pressure and the incidence of cognitive impairment in older adults.
designProspective cohort study.
settingCommunity-living older adults from 22 provinces in China.
participantsWe included 12,281 cognitively normal [Mini-Mental State Examination (MMSE) ≥ 24] older adults (median age: 81 years) from the Chinese Longitudinal Healthy Longevity Survey. Eligible participants must have baseline blood pressure data and have 1 or more follow-up cognitive assessments. MEASUREMENTS: Baseline systolic (SBP) and diastolic blood pressure (DBP) were measured by trained internists. Cognitive function was evaluated by MMSE. We considered mild/moderate/severe cognitive impairment (MMSE <24, and MMSE decline ≥3) as the primary outcome.
resultsThe participants with hypertension had a significantly higher risk of mild/moderate/severe cognitive impairment (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.10-1.24). Overall, the associations with cognitive impairment seem to be hockey stick-shaped for SBP and linear for DBP, though the estimated effects for low SBP/DBP were less precise. High SBP was associated with a gradual increase in the risk of mild/moderate/severe cognitive impairment (P trend < .001). Compared with SBP 120 to 129 mmHg, the adjusted HR was 1.17 (95% CI 1.07-1.29) for SBP 130 to 139 mmHg, increased to 1.54 (95% CI 1.35-1.75) for SBP ≥180 mmHg. Analyses for high DBP showed the same increasing pattern, with an adjusted HR of 1.09 (95% CI 1.01-1.18) for DBP 90 to 99 mmHg and 1.19 (95% CI 1.02-1.38) for DBP ≥110 mmHg, as compared with DBP 70 to 79 mmHg.
conclusionLate-life high blood pressure was independently associated with cognitive impairment in cognitively normal Chinese older adults. Prevention and management of high blood pressure may have substantial benefits for cognition among older adults in view of the high prevalence of hypertension in this rapidly growing population.
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