ArticleThe Journal of infection2019
Prevalence of rotavirus and rapid changes in circulating rotavirus strains among children with acute diarrhea in China, 2009-2015.
Article in The Journal of infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 6 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 6 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021.Human vaccines & immunotherapeutics · 2025Pooled it
- Disease burden of rotavirus related diarrhea in children under 5 years in China: a meta-analysis.Scientific reports · 2025Pooled it
- Epidemiology, genetic diversity and symptom characterization ofFrontiers in microbiology · 2025Pooled it
- Prevalence and genetic diversity of rotavirus in Bangladesh during pre-vaccination period, 1973-2023: a meta-analysis.Frontiers in immunology · 2023Pooled it
- Infection status and circulating strains of rotaviruses in Chinese children younger than 5-years old from 2011 to 2018: systematic review and meta-analysis.Human vaccines & immunotherapeutics · 2021Pooled it
- Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea.Scientific reports · 2019Pooled it
- Randomized controlled trial evaluating immunogenicity and safety of a porcine circovirus-free rotavirus vaccine in healthy Chinese infants.Human vaccines & immunotherapeutics · 2026Trial
- Incidence rate of rotavirus-associated diarrhea in Pudong New Area, Shanghai, China, during the period 2018-2022.BMC infectious diseases · 2026Article
- Prevalence of group A rotavirus G and P genotypes in children with acute gastroenteritis in China from 2020 to 2021.Archives of virology · 2026Article
- Pediatric Rotavirus A Infection Among 337,019 Participants Within Asia: A Pan-Asian Systematic Review and Meta-Analysis.Journal of tropical medicine · 2026Review
- The impact of El Niño-Southern Oscillation on the incidence of infectious diarrhea in China: insights from a 15-year national surveillance analysis.Frontiers in public health · 2026Article
- Epidemiological characteristics of Group A rotavirus diarrhea in children under 5 years old in China from 2009 to 2020.BMC infectious diseases · 2025Article
- Article
- The 2Human vaccines & immunotherapeutics · 2024Article
- Bovine Colostrum in Pediatric Nutrition and Health.Nutrients · 2024Review
- Frequency and genotyping of group A rotavirus among Egyptian children with acute gastroenteritis: a hospital-based cross-sectional study.Virology journal · 2024Article
- Driving forces of continuing evolution of rotaviruses.World journal of virology · 2024Review
- Genetic diversity of G9, G3, G8 and G1 rotavirus group A strains circulating among children with acute gastroenteritis in Vietnam from 2016 to 2021.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024Article
- Cost-effectiveness analysis of introducing rotavirus vaccine into immunization program in Zhejiang province, China: A decision tree-Markov model study.Human vaccines & immunotherapeutics · 2023Article
- Article
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Authors and funding
14 authors at 3 institutions in 5 countries.
Funding
Abstract
backgroundRotavirus is a leading cause of morbidity and mortality in young children worldwide. In China, the universal immunization of children with the rotavirus vaccine has not been introduced, and the two globally distributed vaccines (RotaTeq and Rotarix) are not licensed in the country. We aim to determine the prevalence and strain diversity of rotavirus in children with diarrhea aged ≤ five years across China. MATERIALS AND
methodsSentinel-based surveillance of acute diarrhea was conducted at 213 participating hospitals in China from January 1, 2009, through December 31, 2015. Group A rotavirus (RVA) was tested by using enzyme-linked immunosorbent assays, and G- and P-genotype of RVA were tested by RT-PCR methods.
resultsOf 33,616 children with diarrhea, 10,089 (30%) were positive for RVA; RVA-associated diarrhea was identified in 2247 (39.5%, n = 2247/5685) inpatients and 7842 (28.1%, n = 7842/27931) outpatients. Children living in low-middle-income regions suffered from the highest burden of rotavirus, with 40.7% of diarrhea cases attributed to rotavirus infection, followed by 31.3% in upper-middle-income and 11.2% in high-income regions. The majority of children (88.9%, n = 8976/10089) who tested positive for RVA were children aged ≤ 2 years. The seasonal peak of RVA was in the winter. Among all 2533 RVA strains genotyped, five strain combinations, G9P[8], G3P[8], G1P[8], G2P[4] and G3P[4], contributed to 71.3% (1807/2533) of the RVA-associated diarrhea cases. The predominant strain of RVA has rapidly evolved from G3P[8] and G1P[8] to G9P[8] in the recent years, with the proportion of G9P[8] having increased remarkably from 3.4% in 2009 to 60.9% in 2015.
conclusionsThe burden of diarrhea attributed to rotavirus is high in China, highlighting the potential value of vaccination. The rapid shift of RVA strains highlights the importance of conducting rotavirus surveillance to ensure that currently marketed vaccines provide protective efficacy against the circulating strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.