Evidence map›Paper›PMID 30017591›Full record

ArticleCell stem cell2018

PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ.

Bo Yu, Lihong Huo, Yunsong Liu, Peng Deng, John Szymanski, Jiong Li, Xianghang Luo, Christine Hong, Jiandie Lin, Cun-Yu Wang

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 186 citations in OpenAlex.

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  20. Isovitexin: A Promising Active Compound Found in Nature's Bounty.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025
    Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Bo YuLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: boyu@dentistry.ucla.edu.
Lihong HuoLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yunsong LiuDepartment of Prosthodontics, School of Stomatology, Peking University, Beijing 100081, China.
Peng DengLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
John SzymanskiLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jiong LiLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xianghang LuoDepartment of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, People's Republic of China.
Christine HongDivision of Growth and Development, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jiandie LinLife Sciences Institute, Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Cun-Yu WangLaboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, Broad Stem Cell Research Center and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: cwang@dentistry.ucla.edu.
University of California, Los Angeles · USCentral South University · CNPeking University · CNUniversity of Michigan · US

Funding

The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
Wnt-4 inhibits peridontitis by attenuating NF-kBR01DE019412 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, CUN-YU · 2008 to 2021
$5.7M
Molecular Regulation of MSC fate Decision and Bone Formation by PGC-1aR01DE024828 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HONG, CHRISTINE, WANG, CUN-YU · 2017 to 2021
$2.2M
Molecular Control of MSC differentiation and Bone Formation by KDM4BR01AR063089 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, CUN-YU · 2013 to 2017
$1.6M
Promoting DMSC-mediated craniofacial regeneration by estrogenK08DE024603 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HONG, CHRISTINE · 2014 to 2018
$666k
NCATS NIH HHS KL2 TR001882NIAMS NIH HHS R01 AR063089NIDCR NIH HHS K08 DE024603NIDCR NIH HHS R01 DE019412NIDCR NIH HHS R01 DE024828
6 · The paper itself

Abstract

Aberrant lineage specification of skeletal stem cells (SSCs) contributes to reduced bone mass and increased marrow adipose tissue (MAT) in osteoporosis and skeletal aging. Although master regulators of osteoblastic and adipogenic lineages have been identified, little is known about factors that are associated with MAT accumulation and osteoporotic bone loss. Here, we identify peroxisome-proliferator-activated receptor γ coactivator 1-α (PGC-1α) as a critical switch of cell fate decisions whose expression decreases with aging in human and mouse SSCs. Loss of PGC-1α promoted adipogenic differentiation of murine SSCs at the expense of osteoblastic differentiation. Deletion of PGC-1α in SSCs impaired bone formation and indirectly promoted bone resorption while enhancing MAT accumulation. Conversely, induction of PGC-1α attenuated osteoporotic bone loss and MAT accumulation. Mechanistically, PGC-1α maintains bone and fat balance by inducing TAZ. Our results suggest that PGC-1α is a potentially important therapeutic target in the treatment of osteoporosis and skeletal aging.

Indexed as

Adaptor Proteins, Signal TransducingAdipose TissueAdultAgedAged, 80 and overAgingAnimalsBone and BonesFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalAdaptor Proteins, Signal TransducingIntracellular Signaling Peptides and ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanPpargc1a protein, mouseTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWWTR1 protein, humanWwtr1 protein, mouseagingbonefatlineage decisionmesenchymal stem cellsosteoporosisPGC-1αskeletal stem cellsTAZ

Identifiers

PMID30017591
PMCPMC6322535
OpenAlexW2884426132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.