ArticleCurrent biology : CB2018
A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia.
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Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
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37 citing papers in PubMed.
- Prolactin receptor signalling contributes to the attenuation of stress-induced hyperthermia during pregnancy.Journal of neuroendocrinology · 2026Article
- Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms.iScience · 2026Article
- A hypothalamic circuit for circadian regulation of corticosterone secretion.Nature communications · 2026Article
- Thermoregulatory Dysfunction in Parkinson's Disease: Mechanisms, Implications, and Therapeutic Perspectives.Cells · 2025Review
- Article
- Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.bioRxiv : the preprint server for biology · 2025Article
- Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss.Metabolism: clinical and experimental · 2025Article
- Inhibition of the hypothalamic ventromedial periventricular area activates a dynorphin pathway-dependent thermoregulatory inversion in rats.Current biology : CB · 2025Article
- TRPV4 activation by core body temperature has multimodal functions in the central nervous system.The journal of physiological sciences : JPS · 2024Review
- Neural cell-types and circuits linking thermoregulation and social behavior.Neuroscience and biobehavioral reviews · 2024Review
- AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin's acute effects.Nature communications · 2024Article
- Longitudinal genomic analyses of automatically-recorded vaginal temperature in lactating sows under heat stress conditions based on random regression models.Genetics, selection, evolution : GSE · 2023Article
- A parabrachial-hypothalamic parallel circuit governs cold defense in mice.Nature communications · 2023Article
- Interactions between central nervous system and peripheral metabolic organs.Science China. Life sciences · 2022Review
- Neural circuits mediating circulating interleukin-1β-evoked fever in the absence of prostaglandin E2 production.Brain, behavior, and immunity · 2022Article
- Median preoptic GABA and glutamate neurons exert differential control over sleep behavior.Current biology : CB · 2022Article
- Central Neural Circuits Orchestrating Thermogenesis, Sleep-Wakefulness States and General Anesthesia States.Current neuropharmacology · 2022Review
- Genetic identification of preoptic neurons that regulate body temperature in mice.Temperature (Austin, Tex.) · 2022Review
- Thermoregulation in mice: The road to understanding torpor hypothermia and the shortcomings of a circuit for generating fever.Temperature (Austin, Tex.) · 2022Article
- Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.Science advances · 2021Article
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Authors and funding
9 authors.
Natalia L S MachadoDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA; Department of Physiology and Biophysics, Federal University of Minas Gerais, Antonio Carlos Avenue, Belo Horizonte 31270-901, Brazil.
Stephen B G AbbottDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA; Department of Pharmacology, University of Virginia, Jefferson Park Avenue, Charlottesville, VA 22908, USA.
Jon M ReschDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA.
Lin ZhuDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA.
Elda ArrigoniDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA.
Bradford B LowellDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA.
Patrick M FullerDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA.
Marco A P FontesDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Antonio Carlos Avenue, Belo Horizonte 31270-901, Brazil.
Clifford B SaperDepartment of Neurology, Beth Israel-Deaconess Medical Center, Harvard Medical School, Blackfan Circle, Boston, MA 02215, USA. Electronic address: csaper@bidmc.harvard.edu.
Funding
Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1MThe routing of hunger/satiety information by the parabrachial nucleus (PBN)R01DK075632 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BRADFORD B LOWELL · 2006 to 2026
$8.1MAGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream EffectorsR01DK096010 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2012 to 2024
$7.2MCircuitry for Circadian RhythmsR01NS072337 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2010 to 2023
$4.8MHypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8MGlutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of SatietyR01DK111401 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2016 to 2020
$2.2MBasal forebrain hypothalamic networks supporting wakefulnessR01NS091126 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ARRIGONI, ELDA · 2015 to 2019
$1.9MNHLBI NIH HHS P01 HL095491NIDDK NIH HHS R01 DK075632NIDDK NIH HHS R01 DK096010NIDDK NIH HHS R01 DK111401NINDS NIH HHS R01 NS072337NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS091126
Abstract
Stress elicits a variety of autonomic responses, including hyperthermia (stress fever) in humans and animals. In this present study, we investigated the circuit basis for thermogenesis and heat conservation during this response. We first demonstrated the glutamatergic identity of the dorsal hypothalamic area (DHA
Indexed as
ThermogenesisAnimalsBody Temperature RegulationFemaleFeverHypothalamusMaleMiceNeuronsNucleus Raphe PallidusOptogeneticsStress, Physiologicaldorsal hypothalamic areafeverhypothalamusmedullaraphe pallidusstress-induced hyperthermia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.