ArticleNeuron2018
Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Attractive and repulsive couplings between circadian pacemaker neurons promote entrainment to light-dark cycles with after-effect.Npj biological timing and sleep · 2026Article
- Interpretable machine learning reveals hemispheric asymmetry of state switching in the suprachiasmatic nucleus.Patterns (New York, N.Y.) · 2026Article
- Article
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- A direct SCN-to-DMH output pathway organizes circadian behavioral timing.bioRxiv : the preprint server for biology · 2026Article
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- Metaplastic sleep regulation inbioRxiv : the preprint server for biology · 2026Article
- Diurnality reconfigures circadian network dynamics in the suprachiasmatic nucleus.bioRxiv : the preprint server for biology · 2026Article
- Neuronal feedback loop of the suprachiasmatic nucleus generates robust circadian rhythms.Nature communications · 2026Article
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.Molecular metabolism · 2026Article
- The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms.The Journal of clinical investigation · 2025Article
- Molecular Links Between Circadian Rhythm Disruption, Melatonin, and Neurodegenerative Diseases: An Updated Review.Molecules (Basel, Switzerland) · 2025Review
- Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus.Nature communications · 2025Article
- Mechanistic insights into chemotherapy-induced circadian disruption using rodent models.Trends in neurosciences · 2025Review
- Expression of a pheromone binding protein affected by timeless gene governs female mating behavior in Bactrocera dorsalis.BMC biology · 2025Article
- Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host.Cancer cell · 2025Article
- Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNCommunications biology · 2024Article
- The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus.bioRxiv : the preprint server for biology · 2024Article
- Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.bioRxiv : the preprint server for biology · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker, integrating environmental input to align physiological and behavioral rhythms to local time cues. Approximately 10% of SCN neurons express vasoactive intestinal polypeptide (VIP); however, it is unknown how firing activity of VIP neurons releases VIP to entrain circadian rhythms. To identify physiologically relevant firing patterns, we optically tagged VIP neurons and characterized spontaneous firing over 3 days. VIP neurons had circadian rhythms in firing rate and exhibited two classes of instantaneous firing activity. We next tested whether physiologically relevant firing affected circadian rhythms through VIP release. We found that VIP neuron stimulation with high, but not low, frequencies shifted gene expression rhythms in vitro through VIP signaling. In vivo, high-frequency VIP neuron activation rapidly entrained circadian locomotor rhythms. Thus, increases in VIP neuronal firing frequency release VIP and entrain molecular and behavioral circadian rhythms. VIDEO ABSTRACT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.