Evidence map›Paper›PMID 30017358›Full record

ArticleCell metabolism2018

CalR: A Web-Based Analysis Tool for Indirect Calorimetry Experiments.

Amir I Mina, Raymond A LeClair, Katherine B LeClair, David E Cohen, Louise Lantier, Alexander S Banks

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 315 papers.

0numbers the graph read from it
0cells of the map it votes in
315citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

315 citing papers in PubMed, 470 citations in OpenAlex.

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  15. Sustained loss ofbioRxiv : the preprint server for biology · 2026
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255 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Amir I MinaDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
Raymond A LeClairSpringbok LLC, Boston, MA 02109, USA.
Katherine B LeClairDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
David E CohenDivision of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY 10065, USA.
Louise LantierDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37212, USA.
Alexander S BanksDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. Electronic address: abanks@bwh.harvard.edu.
Brigham and Women's Hospital · USCornell University · USVanderbilt University · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLDR01DK056626 · NIDDK · YESHIVA UNIVERSITY · PI COHEN, DAVID E. · 2000 to 2024
$10.3M
Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLDR01DK103046 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVID E. COHEN, Susan J Hagen · 2015 to 2026
$7.6M
Regulation of Hepatic Lipid and Glucose Metabolism by Phosphatidylcholine TransfeR01DK048873 · NIDDK · YESHIVA UNIVERSITY · PI DAVID E. COHEN · 2003 to 2026
$5.8M
Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2R37DK048873 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI COHEN, DAVID E. · 2012 to 2021
$5.5M
Mechanism of Gdf3 action to limit insulin sensitivity in obesityR01DK107717 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BANKS, ALEXANDER · 2016 to 2023
$3.8M
Comprehensive Lab Animal Monitor System (CLAMS) for the Study of Mouse MetabolismS10OD020100 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI BANKS, ALEXANDER · 2015 to 2015
$419k
MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETIONR29DK048873 · NIDDK · YESHIVA UNIVERSITY · PI COHEN, DAVID E · 1996 to 2000
$147k
NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK048873NIDDK NIH HHS R01 DK056626NIDDK NIH HHS R01 DK103046NIDDK NIH HHS R01 DK107717NIDDK NIH HHS R29 DK048873NIDDK NIH HHS R37 DK048873NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255NIH HHS S10 OD020100
6 · The paper itself

Abstract

We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CalR simplifies the process to import raw data files, generate plots, and determine the most appropriate statistical tests for interpretation. Analysis using the generalized linear model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting diverse experimental designs, including those of obesity and thermogenesis. Users also may produce standardized output files for an experiment that can be shared and subsequently re-evaluated using CalR. This framework will provide the transparency necessary to enhance consistency, rigor, and reproducibility. The CalR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed per accepted norms, and reproduced and will likely become a standard tool for the field. CalR is accessible at https://CalRapp.org/.

Indexed as

Cloud ComputingWeb BrowserWorkflowAnalysis of VarianceAnimalsCalorimetry, IndirectData VisualizationEnergy MetabolismHumansLinear ModelsMiceObesityPulmonary Gas ExchangeReproducibility of ResultsThermogenesisWeight LossANCOVAbiostatisticsCLAMSenergy balanceenergy expenditurefood intakeindirect calorimetrymetabolic phenotypingmetabolismreproducibility

Identifiers

PMID30017358
PMCPMC6170709
OpenAlexW2950484331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.