ArticleCell metabolism2018
Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles.
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Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
36 citing papers in PubMed, 50 citations in OpenAlex.
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- The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights.Cellular & molecular biology letters · 2024Review
- Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice.Journal of Alzheimer's disease : JAD · 2024Article
- Blood RNA transcripts reveal similar and differential alterations in fundamental cellular processes in Alzheimer's disease and other neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Disruption of axonal transport in neurodegeneration.The Journal of clinical investigation · 2023Review
- REEP1 Preserves Motor Function in SOD1Neuroscience bulletin · 2023Article
- Mitochondrial Mutations Can Alter Neuromuscular Transmission in Congenital Myasthenic Syndrome and Mitochondrial Disease.International journal of molecular sciences · 2023Review
- Reversing Dysdynamism to Interrupt Mitochondrial Degeneration in Amyotrophic Lateral Sclerosis.Cells · 2023Review
- Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction.Nature chemical biology · 2023Article
- Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models.International journal of molecular sciences · 2022Article
- Mitochondrial Dysfunction in Spinal Muscular Atrophy.International journal of molecular sciences · 2022Review
- Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration.Aging cell · 2022Review
- Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions.Aging and disease · 2021Review
- Cellular senescence links mitochondria-ER contacts and aging.Communications biology · 2021Review
- Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity.Journal of medicinal chemistry · 2021Article
- Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.Nature communications · 2021Article
- Mitochondrial function in development and disease.Disease models & mechanisms · 2021Review
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Authors and funding
20 authors at 3 institutions in 1 country.
Luwen WangDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Ju GaoDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Jingyi LiuDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Sandra L SiedlakDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Sandy TorresDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Hisashi FujiokaElectron Microscopy Core Facility, Case Western Reserve University, Cleveland, OH, USA.
Mikayla L HuntleyDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Yinfei JiangDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Haiyan JiDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Tingxiang YanDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Micah HarlandDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Pichet TermsarasabDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Sophia ZengDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Zhen JiangDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA.
Jingjing LiangDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
George PerryCollege of Sciences, University of Texas at San Antonio, San Antonio, TX, USA.
Charles HoppelDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
Cheng ZhangDepartment of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Hu LiDepartment of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Xinglong WangDepartment of Pathology, Case Western Reserve University, Cleveland, OH, USA; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA. Electronic address: xinglong.wang@case.edu.
Case Western Reserve University · USMayo Clinic · USThe University of Texas at San Antonio · US
Funding
Capturing the molecular complexity of Alzheimer's disease through the lens of RNA binding proteinsRF1AG056318 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LI, HU, WOLOZIN, BENJAMIN L · 2018 to 2020
$4.4MImmunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4MDeterminants of pancreatic cancer and malignant melanoma phenotypes in CDKN2A hereditary kindredsR01CA208517 · NCI · MAYO CLINIC ROCHESTER · PI FERNANDEZ-ZAPICO, MARTIN ERNESTO, LI, HU · 2016 to 2020
$2.9MMitochondrial dynamics for the maintenance of neuromuscular junctions during aging and in ALSR01NS097679 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, XINGLONG · 2017 to 2021
$2.0MTDP-43 and Mitochondrial Dysfunction in ALSR01NS089604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI WANG, XINGLONG · 2014 to 2018
$1.7MA network platform to connect drug response and prognosis phenotypes for cancersR01CA196631 · NCI · MAYO CLINIC ROCHESTER · PI LI, HU · 2016 to 2018
$1.2MNCI NIH HHS R01 CA196631NCI NIH HHS R01 CA208517NIAID NIH HHS T32 AI089474NIA NIH HHS RF1 AG056318NINDS NIH HHS R01 NS089604NINDS NIH HHS R01 NS097679
Abstract
Skeletal muscles undergo atrophy in response to diseases and aging. Here we report that mitofusin 2 (Mfn2) acts as a dominant suppressor of neuromuscular synaptic loss to preserve skeletal muscles. Mfn2 is reduced in spinal cords of transgenic SOD1
Indexed as
Muscle, SkeletalAgingAmyotrophic Lateral SclerosisAnimalsAxonal TransportCalcium-Binding ProteinsDisease Models, AnimalGTP PhosphohydrolasesHumansMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicMitochondrial ProteinsMuscular AtrophyRatsCalcium-Binding ProteinscalpastatinGTP PhosphohydrolasesMembrane ProteinsMfn2 protein, mouseMitochondrial Proteinsamyotrophic lateral sclerosisaxonal transportcalpastatinMfn2mitochondriamitochondria-associated membranesnerve injuryneuromuscular synapsesarcopeniaskeletal muscle atrophy
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