Evidence map›Paper›PMID 30017086›Full record

ArticleCellular immunology2018

IL10 restrains autoreactive B cells in transgenic mice expressing inactive RAG1.

Victoria L Palmer, Alexandra N Worth, Robyn L Scott, Greg A Perry, Mei Yan, Quan-Zhen Li, Patrick C Swanson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Victoria L PalmerDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Alexandra N WorthDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Robyn L ScottDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Greg A PerryDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Mei YanMicroarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Quan-Zhen LiDepartment of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Patrick C SwansonDepartment of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA. Electronic address: pswanson@creighton.edu.
Creighton University · USThe University of Texas Southwestern Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
CONSTRUCTION OF RESEARCH FACILITYC06RR017417 · NCRR · CREIGHTON UNIVERSITY · PI WILSON, M. ROY · 2002 to 2002
$2.0M
Replacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638k
Implications of B10-like cell expansion in a model of impaired receptor editingR21AI119829 · NIAID · CREIGHTON UNIVERSITY · PI SWANSON, PATRICK C. · 2017 to 2018
$400k
NCRR NIH HHS C06 RR017417NCRR NIH HHS G20 RR024001NIAID NIH HHS R21 AI119829NIGMS NIH HHS P20 GM103427
6 · The paper itself

Abstract

IL10 plays a dual role in supporting humoral immunity and inhibiting inflammatory conditions. B cells producing IL10 are thought to play a key regulatory role in maintaining self-tolerance and suppressing excessive inflammation during autoimmune and infectious diseases, primarily by inhibiting associated T cell responses. The extent to which B cells, through the provision of IL10, might function to sustain or inhibit autoantibody production is less clear. We previously described transgenic mice expressing catalytically inactive RAG1 (dnRAG1 mice), which show expansion of an IL10-compentent CD5

Indexed as

AnimalsAutoantigensB-Cell Activating FactorB-LymphocytesB-Lymphocyte SubsetsCD5 AntigensCell DifferentiationCell ProliferationCells, CulturedHomeodomain ProteinsInterleukin-10Mice, KnockoutMice, TransgenicSelf ToleranceSpleenAutoantigensB-Cell Activating FactorCD5 AntigensHomeodomain ProteinsInterleukin-10RAG-1 proteinTnfsf13b protein, mouseAutoantibodyB10 B cellsBAFFCD5(+) B cellsIL10Natural antibodyRegulatory B cells

Identifiers

PMID30017086
PMCPMC7189341
OpenAlexW2807870982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.