Evidence map›Paper›PMID 30017022›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2018

Community outbreak of serogroup B invasive meningococcal disease in Beaujolais, France, February to June 2016: from alert to targeted vaccination.

Alexandra Thabuis, Karim Tararbit, Muhamed-Kheir Taha, Dominique Dejour-Salamanca, Vincent Ronin, Isabelle Parent du Chatelet, Guillaume Spaccaferri

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. 4CMenB journey to the 10-year anniversary and beyond.Human vaccines & immunotherapeutics · 2024
    Review
  5. Article
  6. Genetic characterization ofFrontiers in cellular and infection microbiology · 2024
    Article
  7. Review
  8. Article
  9. Outbreak of invasive meningococcal disease caused by a meningococcus serogroup B in a nursery school, Wallonia, Belgium, 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Article
  10. Review
  11. First report of meningococcal ciprofloxacin resistance in Greece due to invasive isolates of the sequence type ST-3129.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  12. Article
  13. Epidemiological profile ofAccess microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra ThabuisSanté publique France, French national public health agency, Cellule d'intervention en région Auvergne-Rhône-Alpes, Saint-Maurice, France.
Karim TararbitAgence régionale de santé Auvergne-Rhône-Alpes, Regional health agency, Lyon, France.
Muhamed-Kheir TahaInstitut Pasteur, National Reference Centre for Meningococci, Paris, France.
Dominique Dejour-SalamancaAgence régionale de santé Auvergne-Rhône-Alpes, Regional health agency, Lyon, France.
Vincent RoninAgence régionale de santé Auvergne-Rhône-Alpes, Regional health agency, Lyon, France.
Isabelle Parent du ChateletSanté publique France, French national public health agency, Department of Infectious Diseases, Saint-Maurice, France.
Guillaume SpaccaferriSanté publique France, French national public health agency, Cellule d'intervention en région Auvergne-Rhône-Alpes, Saint-Maurice, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In February and March 2016, four cases of serogroup B invasive meningococcal disease (IMD) occurred over 3 weeks in a small area north of Lyon in the Auvergne-Rhône-Alpes region, France. There were no deaths but two cases had sequelae. This community outbreak was caused by a rare meningococcal strain of the clonal complex ST-32, covered by the 4CMenB/Bexsero vaccine. The incidence rate for serogroup B IMD in this area was 22.5 per 100,000 inhabitants, which is above the epidemic threshold (10/100,000). The number of cases observed was significantly higher than expected in the age group of 0-24 year-olds (standardised incidence ratio: 96). These results suggested the potential emergence of this invasive strain in this sub-population. In accordance with French recommendations, it was decided to vaccinate the population aged between 2 months and 24 years, living, working or studying in the epidemic area. The vaccination campaign took place from April to September 2016. Vaccination coverage was estimated at 47% for one dose and 40% for two doses. The lowest coverage estimations were observed for the age groups younger than 3 and 15-19 years. Enhanced epidemiological and microbiological surveillance reported a fifth case in June 2016, outside the epidemic area.

Indexed as

Disease OutbreaksAdolescentChildChild, PreschoolFemaleFranceHumansImmunization ProgramsIncidenceInfantInfant, NewbornInfection ControlMaleMeningococcal InfectionsMeningococcal VaccinesNeisseria meningitidis, Serogroup B4CMenB vaccineMeningococcal Vaccines4CMenB/Bexseroinvasive meningococcal diseaseoutbreakserogroup Bvaccination campaign

Identifiers

PMID30017022
PMCPMC6152148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.