Evidence map›Paper›PMID 30017020›Full record

ArticleComparative medicine2018

Refinement and Successful Implementation of a Scoring System for Myxomatosis in a Susceptible Rabbit (

A Marissa Wolfe, Masmudur Rahman, D Grant McFadden, Eric C Bartee

Abstract read
In one paragraph

Article in Comparative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

A Marissa WolfeDepartments of Comparative Medicine, Medical University of South Carolina, Charleston, South Carolina.
Masmudur RahmanBiodesign Institute, Arizona State University, Tempe, Arizona, USA.
D Grant McFaddenBiodesign Institute, Arizona State University, Tempe, Arizona, USA.
Eric C BarteeDepartments of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA. bartee@musc.edu.
Arizona State University · USMedical University of South Carolina · US

Funding

Studies in Poxvirus Host Range Genes and TropismR01AI080607 · NIAID · UNIVERSITY OF FLORIDA · PI RAHMAN, MASMUDUR MOHAMMED · 2009 to 2025
$5.6M
Treatment of multiple myeloma using oncolytic myxoma virusR01CA194090 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BARTEE, ERIC CARTER · 2016 to 2020
$1.7M
Impact of envelope proteins on poxviral pathogenesisR21AI123803 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BARTEE, ERIC CARTER · 2016 to 2017
$411k
NCI NIH HHS R01 CA194090NIAID NIH HHS R01 AI080607NIAID NIH HHS R21 AI123803
6 · The paper itself

Abstract

Myxoma virus is a member of Leporipoxviridae whose tropism is tightly restricted to lagomorphs. In susceptible Oryctolagus rabbits, the virus causes a highly lethal disease known as myxomatosis, which begins as a localized infection but rapidly disseminates throughout the animal, leading to immune compromise, mucosal infections, multiorgan failure, and death. In a research setting, myxoma infection of susceptible Oryctolagus cuniculus rabbits is used as a model of poxviral disease progression and represents one of only a few means to study the pathogenesis of this viral family in a native host species. However, the rapid progression of myxomatosis makes accurate prediction of humane endpoints critical to limiting animal pain and distress and preventing death as an endpoint. Here we present case studies of myxomatosis at 2 institutions and offer a refined scoring system to reliably track the course of disease in susceptible rabbits infected with myxoma virus.

Indexed as

Animal WelfareMyxoma virusAnimalsDisease Models, AnimalDisease SusceptibilityFemalePoxviridae InfectionsRabbitsReproducibility of ResultsResearch DesignVirulence

Identifiers

PMID30017020
PMCPMC6103426
OpenAlexW2883425210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.