ArticleBMC gastroenterology2018
Male sex and history of ischemic heart disease are major risk factors for anastomotic leakage after laparoscopic anterior resection in patients with rectal cancer.
Article in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Role of transanal drainage tubes in preventing anastomotic leakage after low anterior resection: a meta-analysis of randomized controlled trials.Techniques in coloproctology · 2022Pooled it
- Trial
- Transanal drainage tube versus diverting stoma for reducing anastomotic leakage after rectal cancer surgery: a systematic review and meta-analysis.Journal of gastrointestinal oncology · 2026Article
- The Ratio of Visceral to Subcutaneous Adipose Tissue Is Associated With Postoperative Anastomotic Leakage in Patients With Rectal Cancer With Gender Differences in Opposite Direction.Cancer medicine · 2025Article
- Operative Time as a Universal Risk Factor for Infectious Complications after Colorectal Cancer Surgery: A Multicenter Stratified Analysis by Surgical Site.Journal of the anus, rectum and colon · 2025Article
- Evaluation of intestinal tissue safety during the compression process of circular end-to-end anastomosis stapler based on finite element simulation.Frontiers in bioengineering and biotechnology · 2025Article
- The impact of transanal drainage tube on the incidence of anastomotic leakage and small bowel obstruction in radical surgery (Dixon) for rectal cancer: a retrospective cohort study.Journal of gastrointestinal oncology · 2024Article
- Safety and Efficacy Analysis of Radical Surgery for 403 Patients with Colon Cancer over 80 Years Old.Journal of Cancer · 2024Article
- Retrospective study of active drainage in the management of anastomotic leakage after anterior resection for rectal cancer.The Journal of international medical research · 2021Article
- Feasibility of endoscopic hand suturing on rectal anastomoses in ex vivo porcine models.Scientific reports · 2021Article
- Diagnosis of Anastomotic Leak.Clinics in colon and rectal surgery · 2021Review
- Machine learning-based random forest predicts anastomotic leakage after anterior resection for rectal cancer.Journal of gastrointestinal oncology · 2021Article
- Determining the protective characteristics and risk factors for the development of anastomotic leakage after low anterior resection for rectal cancer.Surgery today · 2021Article
- Protective ileostomy does not prevent anastomotic leakage after anterior resection of rectal cancer.The Journal of international medical research · 2020Article
- Early renal dysfunction after temporary ileostomy construction.Surgery today · 2020Article
- Preoperative lymphocyte-to-monocyte ratio predicts postoperative infectious complications after laparoscopic colorectal cancer surgery.International journal of clinical oncology · 2020Article
- A Retrospective Study of Risk Factors for Symptomatic Anastomotic Leakage after Laparoscopic Anterior Resection of the Rectal Cancer without a Diverting Stoma.Gastroenterology research and practice · 2020Article
- Intraoperative intraperitoneal chemotherapy increases the incidence of anastomotic leakage after anterior resection of rectal tumors.World journal of gastrointestinal oncology · 2019Article
- The Clinical and Economic Burden of Colorectal Anastomotic Leaks: Middle-Income Country Perspective.Gastroenterology research and practice · 2019Article
- Diverting StomaIn vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aimed to determine risk factors for AL after laparoscopic anterior resection (AR) of rectal cancer.
methodsThis retrospective cohort study extracted information from a prospective database of all consecutive colorectal resections that proceeded at Nippon Medical School Hospital between January 2011 and December 2015 (n = 865). We identified 154 patients with rectal cancer treated by elective laparoscopic AR with anastomosis using primary double-stapling. Clinical variables and comorbidity, habits, and surgery-related variables were assessed by univariate and multivariate analyses to determine preoperative risk factors for clinical AL.
resultsThe overall rate of clinical AL was 11.7% (18 of 154 patients), and 5 (27.8%) of 18 patients required revised laparotomy. Data from males were analyzed because AL occurred only in males. Univariate analysis of male patients (n = 100) significantly associated preoperative creatinine values (p = 0.03) and a history of ischemic heart disease (IHD) (p = 0.012) with AL. The frequency of AL tended to increase (p = 0.06) when patients had low AR (p = 0.06) and transanal drainage. Having AL significantly prolonged hospital stays compared with patients without leakage (36.2 vs. 11.1 days; p < 0.01). Multivariate analysis identified a history of IHD (odds ratio [OR], 4.73; 95% confidence interval [CI], 1.27-17.5; p = 0.025] as an independent risk factor for AL.
conclusionsMale sex and a history of IHD are possible risk factors for AL after elective laparoscopic rectal cancer surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.