ArticleNeuropharmacology2018
The α6 subunit-containing GABA
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Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Targeting the microbiome in pediatric migraine: gastrointestinal manifestations and the therapeutic role ofGut microbes · 2026Article
- Hispidulin Isolated from the Leaves of Clerodendrum inerme (L.) Gaertn Suppresses Trigeminovascular System Activation in a Rat Model Mimicking Migraine.Pharmaceutical research · 2025Article
- LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids.ACS omega · 2024Article
- Hypothalamic Paraventricular Stimulation Inhibits Nociceptive Wide Dynamic Range Trigeminocervical Complex Cells via Oxytocinergic Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- TLR4 induced TRPM2 mediated neuropathic pain.Frontiers in pharmacology · 2024Review
- Why Can Modulation of α6-Containing GABAArchives of pharmacology and therapeutics · 2024Article
- The deuterated pyrazoloquinolinone targeting α6 subunit-containing GABAFrontiers in pharmacology · 2024Article
- Cerebellar α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain.Current neuropharmacology · 2021Article
- Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020Article
- Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABAFrontiers in neuroscience · 2020Article
- Two Distinct Populations of α1α6-Containing GABAA-Receptors in Rat Cerebellum.Frontiers in synaptic neuroscience · 2020Article
- Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain.Medicines (Basel, Switzerland) · 2019Review
- Plasma Calcitonin Gene-Related Peptide: A Potential Biomarker for Diagnosis and Therapeutic Responses in Pediatric Migraine.Frontiers in neurology · 2019Article
- Age-Dependent Anti-migraine Effects of Valproic Acid and Topiramate in Rats.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 4 countries.
Pi-Chuan FanDepartment of Pediatrics, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan; Department of Pediatrics, National Taiwan University Hospital, Taipei, 10002, Taiwan; Clinical Center for Neuroscience and Behavioral, National Taiwan University Hospital, Taipei, 10002, Taiwan.
Tzu-Hsuan LaiDepartment of Pediatrics, National Taiwan University Hospital, Taipei, 10002, Taiwan.
Chia Chun HorGraduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Ming Tatt LeeGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan; Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, Malaysia.
Pokai HuangDepartment of Pediatrics, E-da Dachang Hospital, Kaohsiung, 807, Taiwan.
Werner SieghartCenter for Brain Research, Department of Molecular Neurosciences, Medical University Vienna, Vienna, 1090, Wien, Austria.
Margot ErnstCenter for Brain Research, Department of Molecular Neurosciences, Medical University Vienna, Vienna, 1090, Wien, Austria.
Daniel E KnutsonDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, WI, 53211, USA.
James CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, WI, 53211, USA.
Lih-Chu ChiouGraduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan; Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan; Clinical Center for Neuroscience and Behavioral, National Taiwan University Hospital, Taipei, 10002, Taiwan; Graduate Institute of Acupuncture Sciences, China Medical University, Taichung, 404, Taiwan. Electronic address: lcchiou@ntu.edu.tw.
National Taiwan University · TWMedical University of Vienna · ATUniversity of Wisconsin–Milwaukee · USE-Da Hospital · TWNational Taiwan University Hospital · TW
Funding
Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0MDesign of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9MSynthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3MDevelopment of Compounds Targeting xc- for the Treatment of SchizophreniaR43MH083417 · NIMH · PROMENTIS PHARMACEUTICALS, INC. · PI BAKER, DAVID A, COOK, JAMES M · 2008 to 2009
$508kAustrian Science Fund FWF I 2306NHLBI NIH HHS R01 HL118561NIMH NIH HHS R01 MH096463NIMH NIH HHS R43 MH083417NINDS NIH HHS R01 NS076517
Abstract
Novel treatments against migraine are an urgent medical requirement. The α6 subunit-containing GABA
Indexed as
AnimalsAzidesBenzodiazepinesCalcitonin Gene-Related PeptideCapsaicinDiazepamDose-Response Relationship, DrugDura MaterFurosemideGABA-A Receptor AgonistsGABA-A Receptor AntagonistsInfusions, IntraventricularMalePyrazolonesQuinolonesRatsAzidesBenzodiazepinesCalcitonin Gene-Related PeptideCapsaicinDiazepamFurosemideGABA-A Receptor AgonistsGABA-A Receptor AntagonistsloreclezolePyrazolonesPZ-II-029QuinolonesReceptors, GABA-ARo 15-4513TopiramateTriazolesCalcitonin gene-related peptidePositive allosteric modulatorTrigeminal gangliaTrigeminovascular activationα6GABA(A)R
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.