Evidence map›Paper›PMID 30016618›Full record

ReviewDevelopmental cell2018

A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.

Michael N Wosczyna, Thomas A Rando

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Developmental cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04444102 (The Acute Impact of Yoga-based Stretching on Inflammation and Its Resolution), which is not on this map. Cited by 216 papers.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04444102 naunknown statusnot on this mapstarted 2020, after this paper: background citation

The Acute Impact of Yoga-based Stretching on Inflammation and Its Resolution: a Pilot Study

TypeinterventionalSponsorHarvard University Faculty of MedicineRan2020 to 2024Enrolled30ConditionsInflammation, Fascia, Inflammation, Musculoskeletal PainArmsYoga-based stretching
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 362 citations in OpenAlex.

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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael N WosczynaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.
Thomas A RandoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address: rando@stanford.edu.
Stanford Medicine · USVA Palo Alto Health Care System · US

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS A. RANDO · 2011 to 2026
$29.3M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
Systems Modeling of Alzheimers Disease in C. elegansRF1AG057341 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MURPHY, COLEEN TARA, SUH, YOUSIN · 2017 to 2017
$3.7M
A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical ActivityR01AG047820 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A., WYSS-CORAY, TONY · 2013 to 2017
$3.5M
Notch Signaling and Satellite Cell ActivationR37AG023806 · NIA · STANFORD UNIVERSITY · PI RANDO, THOMAS A. · 2010 to 2019
$2.9M
Complement Components as Mediators of Cell and Tissue AgingR01AG055755 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A. · 2017 to 2021
$2.2M
From in vivo to in vitro heterochronic parabiosis to identify geronic factorsR01AG057433 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RANDO, THOMAS A., SUH, YOUSIN · 2017 to 2020
$2.1M
TGF-beta family members and their binding proteins in aging skeletal muscleR01AG052962 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LEE, SE-JIN, RANDO, THOMAS A. · 2017 to 2020
$1.9M
Notch Signaling and Satellite Cell ActivationR01AG023806 · NIA · STANFORD UNIVERSITY · PI RANDO, THOMAS A. · 2005 to 2009
$1.2M
Mesenchymal Stem Cells as Determinants of Tissue AgingK99AG053438 · NIA · STANFORD UNIVERSITY · PI WOSCZYNA, MICHAEL · 2016 to 2017
$202k
Regulation of Muscle Fibrosis in Response to Injury and AgingI01BX002324 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI RANDO, THOMAS A. · 2014 to 2021
–
Muscle Stem Cell Therapy for Volumetric Muscle LossI01RX001222 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI HUANG, NGAN F. · 2014 to 2023
–
BLRD VA I01 BX002324NIA NIH HHS K99 AG053438NIA NIH HHS P01 AG036695NIA NIH HHS R01 AG023806NIA NIH HHS R01 AG047820NIA NIH HHS R01 AG052962NIA NIH HHS R01 AG055755NIA NIH HHS R01 AG057433NIA NIH HHS R37 AG023806NIA NIH HHS RF1 AG057341RRD VA I01 RX001222
6 · The paper itself

Abstract

Skeletal muscle has an extraordinary regenerative capacity due to the activity of tissue-specific muscle stem cells. Consequently, these cells have received the most attention in studies investigating the cellular processes of skeletal muscle regeneration. However, efficient capacity to rebuild this tissue also depends on additional cells in the local milieu, as disrupting their normal contributions often leads to incomplete regeneration. Here, we review these additional cells that contribute to the regenerative process. Understanding the complex interactions between and among these cell populations has the potential to lead to therapies that will help promote normal skeletal muscle regeneration under conditions in which this process is suboptimal.

Indexed as

AdipocytesAnimalsCell CommunicationCell DifferentiationEndothelial CellsFibroblastsHumansMuscle, SkeletalMyoblasts, SkeletalPericytesRegenerationSatellite Cells, Skeletal MuscleStem Cellsagingfatty and fibrotic degenerationfibroadipogenic progenitorsinjurymuscle mesenchymal stem cellsmuscle stem cellsmuscular dystrophyregenerative milieusatellite cellsskeletal muscle regeneration

Identifiers

PMID30016618
PMCPMC6075730
OpenAlexW2883070801

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.