Evidence map›Paper›PMID 30016537›Full record

ArticleBiotechnology and bioengineering2018

Superior protein titers in half the fermentation time: Promoter and process engineering for the glucose-regulated GTH1 promoter of Pichia pastoris.

Roland Prielhofer, Michaela Reichinger, Nina Wagner, Katrien Claes, Christoph Kiziak, Brigitte Gasser, Diethard Mattanovich

Open access · hybridAbstract read
In one paragraph

Article in Biotechnology and bioengineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  8. Review
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  10. Article
  11. Promoters in Pichia pastoris: A Toolbox for Fine-Tuned Gene Expression.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  12. Article
  13. Advances in Metabolic Engineering ofJournal of fungi (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Transcriptomic Analysis ofFrontiers in microbiology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Roland PrielhoferDepartment of Biotechnology, BOKU-University of Natural Resources and Life Sciences Vienna, Muthgasse, Austria.ORCID 0000-0002-6899-4772
Michaela ReichingerLonza AG, Rottenstraße, Visp, Switzerland.
Nina WagnerLonza AG, Rottenstraße, Visp, Switzerland.
Katrien ClaesLonza AG, Rottenstraße, Visp, Switzerland.
Christoph KiziakLonza AG, Rottenstraße, Visp, Switzerland.
Brigitte GasserDepartment of Biotechnology, BOKU-University of Natural Resources and Life Sciences Vienna, Muthgasse, Austria.ORCID 0000-0003-2881-6370
Diethard MattanovichDepartment of Biotechnology, BOKU-University of Natural Resources and Life Sciences Vienna, Muthgasse, Austria.
Lonza (Switzerland) · CHAustrian Centre of Industrial Biotechnology (Austria) · ATBOKU University · ATChristian Doppler Laboratory for Thermoelectricity · ATNovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein production in Pichia pastoris is often based on the methanol-inducible P

Indexed as

Batch Cell Culture TechniquesFermentationMetabolic EngineeringPichiaResponse ElementsGlucoseGlucosecarbon sourcePichia pastoris ( P. pastoris)process engineeringpromoter engineeringrecombinant protein productiontranscription factor binding sites (TFBS)

Identifiers

PMID30016537
PMCPMC6221138
OpenAlexW2884644836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.