Trial reportThe international journal of neuropsychopharmacology2018
Catecholaminergic Modulation of Conflict Control Depends on the Source of Conflicts.
Trial report in The international journal of neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Neurobiological influences on event perception: the role of catecholamines.The international journal of neuropsychopharmacology · 2025Trial
- Catecholaminergic Modulation of Metacontrol Is Reflected by Changes in Aperiodic EEG Activity.The international journal of neuropsychopharmacology · 2024Trial
- Cognitive science theory-driven pharmacology elucidates the neurobiological basis of perception-motor integration.Communications biology · 2022Trial
- Auricular Transcutaneous Vagus Nerve Stimulation Diminishes Alpha-Band-Related Inhibitory Gating Processes During Conflict Monitoring in Frontal Cortices.The international journal of neuropsychopharmacology · 2022Trial
- Learning Experience Reverses Catecholaminergic Effects on Adaptive Behavior.The international journal of neuropsychopharmacology · 2020Trial
- The impact of different decibels of ambient noise on attention.Scientific reports · 2026Article
- Modulation of response inhibition with event-related atVNS showed EEG but no behavioral effects.Scientific reports · 2025Article
- Metacontrol is reflected in phasic but not tonic cognitive control dynamics.Scientific reports · 2025Article
- Exploring Chinese family caregiver vigilance in preventing hospitalized children falls from the attention network theory perspective: a qualitative study.Translational pediatrics · 2025Article
- Neurophysiological insights into catecholamine-dependent tDCS modulation of cognitive control.Communications biology · 2025Article
- Effects of Catecholaminergic and Transcranial Direct Current Stimulation on Response Inhibition.The international journal of neuropsychopharmacology · 2024Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Focusing on cognitive potential as the bright side of mental atypicality.Communications biology · 2022Review
- An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs.Pharmacopsychiatry · 2021Article
- The Downsides of Cognitive Enhancement.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Article
- Anodal tDCS modulates specific processing codes during conflict monitoring associated with superior and middle frontal cortices.Brain structure & function · 2021Article
- Resting theta activity is associated with specific coding levels in event-related theta activity during conflict monitoring.Human brain mapping · 2020Article
- Low and high stimulation frequencies differentially affect automated response selection in the superior parietal cortex - implications for somatosensory area processes.Scientific reports · 2020Article
- Passive perceptual learning modulates motor inhibitory control in superior frontal regions.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To display goal-directed behavior, we must be able to resolve response conflicts that arise from processing various distractors. Such conflicts may be triggered by different kinds of distractor stimuli (e.g., priming and flanker stimuli), but it has remained largely unclear whether the functional and neurobiological underpinnings of both conflict types differ. We therefore investigated the functional relevance of the catecholamines dopamine and norepinephrine, which have been shown to increase the signal-to-noise ratio in neuronal processing and should therefore modulate response conflicts. Methods: In a double-blind, randomized, placebo-controlled study design, we examined the effect of methylphenidate (0.5 mg/kg) on both flanker-induced and priming-induced response conflicts in a group of n=25 healthy young adults. We used EEG recordings to examine event-related potentials in combination with source localization analyses to identify the cognitive-neurophysiological subprocesses and functional neuroanatomical structures modulated by methylphenidate. Results: Compared with placebo, methylphenidate decreased flanker conflicts. This was matched by increased congruency effects in the fronto-central N2/P3 event-related potential complex and associated with modulations in the right inferior frontal gyrus. In contrast to this, methylphenidate did not modulate the size of prime-evoked conflicts. Conclusions: Our results suggest that catecholamine-driven increases in signal-to-noise ratio and neural gain control do not equally benefit differently evoked conflicts. This supports the hypothesis of an at least partly different neurobiological basis for flanker- and prime-evoked response conflicts. As the right inferior frontal gyrus plays an important role in inhibition, the catecholaminergic system may reduce flanker conflicts by supporting the inhibition of distracting information.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.