Evidence map›Paper›PMID 30016351›Full record

Trial reportPloS one2018

Adverse pregnancy outcomes and imbalance in angiogenic growth mediators and oxidative stress biomarkers is associated with advanced maternal age births: A prospective cohort study in Ghana.

Enoch Odame Anto, William K B A Owiredu, Samuel Asamoah Sakyi, Cornelius Archer Turpin, Richard K D Ephraim, Linda Ahenkorah Fondjo, Christian Obirikorang, Eric Adua, Emmanuel Acheampong

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Antioxidants in Pregnancy: Do We Really Need More Trials?Antioxidants (Basel, Switzerland) · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Enoch Odame AntoDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, West Africa.ORCID 0000-0001-9023-6612
William K B A OwireduDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, West Africa.
Samuel Asamoah SakyiDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, West Africa.
Cornelius Archer TurpinDepartment of Obstetrics and Gynaecology, Komfo Anokye Teaching Hospital, Kumasi, Ghana, West-Africa.
Richard K D EphraimDepartment of Medical Laboratory Technology, University of Cape Coast, Cape Coast, Ghana, West Africa.
Linda Ahenkorah FondjoDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, West Africa.
Christian ObirikorangDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, West Africa.
Eric AduaSchool of Medical and Health Sciences (SMHS), Edith Cowan University (ECU), Perth, Western Australia, Australia.
Emmanuel AcheampongDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana, West Africa.
Kwame Nkrumah University of Science and Technology · GHEdith Cowan University · AUKomfo Anokye Teaching Hospital · GHUniversity of Cape Coast · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvanced maternal age (AMA) has been associated with negative pregnancy outcomes. Oxidative stress (OS) and defective placental dysfunction are contributing factors. This study determined the association between AMA and adverse pregnancy outcomes, OS biomarkers and angiogenic growth mediators (AGMs) in normal pregnancies.

methodsThis prospective cohort study conducted at the Obstetrics and Gynaecology (O&G) Department of the Komfo Anokye Teaching Hospital (KATH) finally included 175 normal pregnant women comprising, 58 AMA (35-45 years), 55 (30-34 years) and 62 optimal childbearing age (20-29 years). Venous blood samples were collected at 28-32 weeks for soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PIGF), 8-epiprostaglandinF2-α (8-epi-PGF2α) and total antioxidant capacity (TAC) assays.

resultsPregnancies of AMA had a significantly higher levels of sFlt-1, 8-epi-PGF2α and 8-epi-PGF2α: PIGF ratio but a reduced level of PIGF, TAC and PIGF: sFlt-1 ratio compared to 20-29 years (p<0.0001). A significant negative correlation between AMA and PIGF (r = -0.294; p = 0.038); TAC (r = -0.215; p = 0.001) and PIGF: sFlt-1 ratio (r = -0.457; p<0.0001) and a positive correlation with sFlt-1 (r = 0.269; p = 0.017), 8-epiPGF2α (r = 0.277; p = 0.029) and 8-epi-PGF2: PIGF ratio (r = 0.461; p<0.0001) levels were observed. The adjusted odds ratio (aOR), and 95% confidence interval, and p value for the significant independent adverse outcomes associated with AMA were emergency caesarean section [21.7 (5.9-121.3), p<00001], elective caesarean section [2.7(0.9-5.8), p = 0.0105], stillbirth [12.6(1.4-82.1), p<0.0001], post-partum haemorrhage [4.3(1.1-18.5), p = 0.0094], preterm delivery [8.2(3.5-28.4), p<0.0001], low birth weight babies [9.7(2.8-29.3), p<0.0001], birth asphyxia [3.8(1.6-12.7), p = 0.0054], Apgar score ≤ 7 after 5 min for babies [10.1(4.7-23.2), p<0.0001], placental abruption [3.5(1.3-8.4), p = 0.0117] and intrauterine growth restriction (IUGR) [4.6(2.3-12.9), p = 0.0001].

conclusionAMA pregnancies correlate with adverse pregnancy outcomes and imbalance in OS biomarkers and AGMs. It is incumbent on health care givers to provide effective antenatal care among AMA mothers as early identification of these imbalance and treatment can prevent adverse pregnancy outcomes.

Indexed as

Maternal AgeOxidative StressPregnancy OutcomeAdultAntioxidantsBiomarkersDinoprostFemaleGhanaHumansMembrane ProteinsMiddle AgedPlacenta DiseasesPregnancyVascular Endothelial Growth Factor Receptor-18-epi-prostaglandin F2alphaAntioxidantsBiomarkersDinoprostFLT1 protein, humanMembrane ProteinsPIGF protein, humanVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID30016351
PMCPMC6049923
OpenAlexW2883674073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.