Evidence map›Paper›PMID 30016006›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2019

Behavioral Impact of Long-Term Chronic Implantation of Neural Recording Devices in the Rhesus Macaque.

Colin T Kyle, Michele R Permenter, Julie A Vogt, Peter R Rapp, Carol A Barnes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Neuropsychology of cognitive aging in rhesus monkeys.bioRxiv : the preprint server for biology · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Colin T KyleEvelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
Michele R PermenterCalifornia National Primate Research Center, University of California, Davis, Davis, CA, USA.
Julie A VogtCalifornia National Primate Research Center, University of California, Davis, Davis, CA, USA.
Peter R RappLaboratory of Behavioral Neuroscience, Biomedical Research Center, National Institute on Aging, Baltimore, MD, USA.
Carol A BarnesEvelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.ORCID https://orcid.org/0000-0001-8122-9007
University of Arizona · USUniversity of California, Davis · USNational Institute on Aging · US

Funding

ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HYDE, DALLAS MELVIN · 1985 to 2011
$126.2M
Primate Models of Neurocognitive Aging ZIAAG000352 · NIA · NATIONAL INSTITUTE ON AGING · PI RAPP, PETER R · 2009 to 2025
$20.8M
NEUROBEHAVIORAL RELATIONS IN SENESCENT HIPPOCAMPUSR01AG003376 · NIA · UNIVERSITY OF COLORADO AT BOULDER · PI BARNES, CAROL A. · 1985 to 2025
$16.4M
Representation of spatiotemporal information in human episodic memory and navigationR01NS076856 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ARNE D EKSTROM · 2012 to 2026
$4.8M
COGNITIVE FUNCTION IN THE AGED PRIMATER01AG010606 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MORRISON, JOHN H · 1992 to 2010
$2.5M
COGNITIVE FUNCTION IN THE AGED MONKEYR37AG010606 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RAPP, PETER R · 2006 to 2007
$886k
Intramural Research Program of the National Institute on AgingMcKnight Brain Research FoundationNCRR NIH HHS P51 RR000169NIA NIH HHS R01 AG003376NIA NIH HHS R01 AG010606NIA NIH HHS R37 AG010606NIH HHS AG10606NIH HHS P51 RR000169NIH HHS R01 AG003376NIH HHS R01 NS076856NINDS NIH HHS R01 NS076856
6 · The paper itself

Abstract

backgroundEnsemble recording methods are pervasive in basic and clinical neuroscience research. Invasive neural implants are used in patients with drug resistant epilepsy to localize seizure origin, in neuropsychiatric or Parkinson's patients to alleviate symptoms via deep brain stimulation, and with animal models to conduct basic research. Studies addressing the brain's physiological response to chronic electrode implants demonstrate that the mechanical trauma of insertion is followed by an acute inflammatory response as well as a chronic foreign body response. Despite use of invasive recording methods with animal models and humans, little is known of their effect on behavior in healthy populations.

objectiveTo quantify the effect of chronic electrode implantation targeting the hippocampus on recognition memory performance.

methodsFour healthy female rhesus macaques were tested in a delayed nonmatching-to-sample (DNMS) recognition memory task before and after hippocampal implantation with a tetrode array device.

resultsTrials to criterion and recognition memory performance were not significantly different before vs. after chronic electrode implantation.

conclusionOur results suggest that chronic implants did not produce significant impairments on DNMS performance.

Indexed as

AnimalsCerebrumCognitionElectrodes, ImplantedElectroencephalographyFemaleMacaca mulattaMemoryPsychomotor PerformanceRecognition, PsychologyTime FactorsCognitiondeep brain stimulationhippocampusneural implantrecognition memory

Identifiers

PMID30016006
PMCPMC6336531
OpenAlexW2884860876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.