Observational studyRetina (Philadelphia, Pa.)2019
ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY: Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions.
Observational study in Retina (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Optical coherence tomography angiography analysis methods: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Early retinal microvascular abnormalities in patients with chronic kidney disease.Microcirculation (New York, N.Y. : 1994) · 2019Trial
- Opposing end-node and junction-node remodeling patterns in diabetic patients on optical coherence tomography angiography.Scientific reports · 2026Article
- Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Impact of systemic hypertension on inner retinal layer thickness and macular microvasculature in patients with diabetic retinopathy.Acta diabetologica · 2025Article
- The relationship between ON-OFF function and OCT structural and angiographic parameters in early diabetic retinal disease.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Conbercept combined with 577 nm subthreshold micropulse laser for diabetic macular edema.International journal of ophthalmology · 2025Article
- Investigation of early-stage cardiovascular-kidney-metabolic syndrome on retinal structure and function evaluated by optical coherence tomography angiography.Frontiers in medicine · 2025Article
- Diabetic retinopathy: A review on its pathophysiology and novel treatment modalities.World journal of methodology · 2024Review
- The role of microglia in the development of diabetic retinopathy.npj metabolic health and disease · 2024Review
- Retinal non-perfusion: recognizing and defining what is important.Eye (London, England) · 2024Article
- Variability of Vascular Reactivity in the Retina and Choriocapillaris to Oxygen and Carbon Dioxide Using Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2023Article
- Central and peripheral changes in the retina and choroid in patients with diabetes mellitus without clinical diabetic retinopathy assessed by ultra-wide-field optical coherence tomography angiography.Frontiers in public health · 2023Article
- The impairment of the deep vascular complex in prolonged type 2 diabetes patients without clinical diabetic retinopathy.PloS one · 2022Article
- Retinal Neurodegeneration in Diabetes: an Emerging Concept in Diabetic Retinopathy.Current diabetes reports · 2021Review
- Foveal avascular zone analysis by optical coherence tomography angiography in patients with type 1 and 2 diabetes and without clinical signs of diabetic retinopathy.International ophthalmology · 2021Article
- Article
- Diabetic Retinopathy-An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes.Frontiers in endocrinology · 2019Article
- Perfusion Deficits in Diabetes Without Retinopathy Localize to the Perivenular Deep Capillaries Near the Fovea on OCT Angiography.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeTo assess early retinal microvascular and functional changes in diabetic patients without clinical evidence of diabetic retinopathy with optical coherence tomography angiography and central visual analyzer.
methodsThis was an observational case-control study of diabetic patients without diabetic retinopathy and nondiabetic controls. Patients underwent optical coherence tomography angiography imaging and visual acuity testing using the central visual analyzer. The foveal avascular zone area and the capillary density in the superficial and deep capillary plexuses were measured manually by a masked grader.
resultsSixty eyes from 35 diabetic patients were included in the study group, and 45 eyes from 31 nondiabetic patients were included in the control group. The foveal avascular zone area was not significantly different between the diabetic group and controls (both P > 0.05). The mean capillary density in the deep capillary plexus was significantly lower in diabetic eyes compared with control eyes (P = 0.04). The mean visual acuity in all central visual analyzer modules was significantly decreased in diabetic patients compared with controls (all P < 0.05).
conclusionOptical coherence tomography angiography was able to detect retinal microvascular changes in the deep capillary plexus, and the central visual analyzer showed signs of decreased visual acuity under conditions simulating suboptimal contrast and glare in diabetic patients without diabetic retinopathy.
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