Evidence map›Paper›PMID 30015608›Full record

ArticleEmerging infectious diseases2018

Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab.

Deirdre Nolfi-Donegan, Monica Konar, Vianca Vianzon, Jessica MacNeil, James Cooper, Perrianne Lurie, Judi Sedivy, Xin Wang, Dan M Granoff, Lucy McNamara

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. The genomic epidemiology ofThe Lancet regional health. Western Pacific · 2024
    Article
  11. Characterisation and Immunogenicity ofFrontiers in immunology · 2024
    Article
  12. Non-serogroupableIDCases · 2023
    Article
  13. Non-capsulatedFrontiers in immunology · 2023
    Review
  14. Limitation ofJournal of clinical microbiology · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Detection of the United StatesEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Deirdre Nolfi-Donegan
Monica Konar
Vianca Vianzon
Jessica MacNeil
James Cooper
Perrianne Lurie
Judi Sedivy
Xin Wang
Dan M Granoff
Lucy McNamara
Centers for Disease Control and Prevention · USPennsylvania Department of Health · USUCSF Benioff Children's Hospital · USUniversity of California, San Francisco · US

Funding

Novel vaccine strategies for prevention of N. meningitidis group B diseaseR01AI046464 · NIAID · OMVAX, INC. · PI MOE, GREGORY ROBERT · 2000 to 2024
$12.1M
Research Training Program for Pediatric Subspecialty FellowsT32HD071834 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TERENCE S. DERMODY · 2013 to 2026
$4.7M
The effect of binding of fH to meningococcal fHbp vaccine on antibody protectionR01AI114701 · NIAID · CHILDREN'S HOSPITAL & RES CTR AT OAKLAND · PI BEERNINK, PETER T. · 2015 to 2019
$3.3M
CONSTRUCTION OF THE VACCINE CENTERC06RR016226 · NCRR · CHILDREN'S HOSPITAL &RES CTR AT OAKLAND · PI LUCAS, ALEXANDER H. · 2002 to 2002
$2.0M
NCRR NIH HHS C06 RR016226NIAID NIH HHS R01 AI046464NIAID NIH HHS R01 AI114701NICHD NIH HHS T32 HD071834
6 · The paper itself

Abstract

Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains. We describe a case in which a nongroupable meningococcal strain, which rarely causes disease in healthy persons, caused fatal disease in an eculizumab recipient despite meningococcal vaccination.

Indexed as

AdolescentAntibodies, BacterialAntibodies, Monoclonal, HumanizedFatal OutcomeFemaleHemoglobinuria, ParoxysmalHumansImmunoglobulin GMeningitis, MeningococcalMeningococcal VaccinesNeisseria meningitidisAntibodies, BacterialAntibodies, Monoclonal, HumanizedeculizumabImmunoglobulin GMeningococcal Vaccines4CMenBbacteriaBexseroeculizumabimmunizationMenB-4Cmeningitis/encephalitismeningococcemiameningococciparoxysmal nocturnal hemoglobinuriaSolirisvaccinatedvaccines

Identifiers

PMID30015608
PMCPMC6056112
OpenAlexW2810721991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.