ReviewPolish journal of microbiology2018
Brucella - Virulence Factors, Pathogenesis and Treatment.
Review in Polish journal of microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
125 citing papers in PubMed, 3 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Research hotspots and development trends ofFrontiers in microbiology · 2025Pooled it
- Efficacy ofTransboundary and emerging diseases · 2024Pooled it
- Global Comprehensive Literature Review and Meta-Analysis of Brucella spp. in Swine Based on Publications From 2000 to 2020.Frontiers in veterinary science · 2021Pooled it
- Effect of Brucella effector protein BtpB regulating apoptosis by targeting host protein YWHAZ.Veterinary research · 2026Article
- Spatiotemporal Analysis of the Primary Factors and Risk Quantification of Human Brucellosis Prevention and Control in Zhejiang Province of China.Zoonoses and public health · 2026Article
- Article
- Disruption of Histidine Biosynthesis Impairs Outer Membrane Stability and Intracellular Survival ofMicroorganisms · 2026Article
- Clinical, Microbiological, and Hematological Characteristics of Pediatric Brucellosis in Saudi Arabia: A Single-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- Biochemistry of Human Gut Microbiota: Related Diseases and Dietary Interactions.Molecules (Basel, Switzerland) · 2026Review
- ComparativeVeterinary world · 2026Article
- A multi-source data-based modelling study on brucellosis transmission risk analysis and control strategies in Zhejiang Province, China.BMC infectious diseases · 2026Article
- Sequencing the whole genome of aMicrobiology resource announcements · 2026Article
- BvrR From Brucella abortus Induces Neuroinflammation Through IRE1-Mediated Activation of ATF2 and NF-κB.MicrobiologyOpen · 2026Article
- Phylogeny-guided multi-epitope vaccine design targeting conserved and divergent regions of Brucella OMP2, OMP25, and OMP31: an immunoinformatics study.BMC immunology · 2026Article
- Integrated in vivo and in silico analysis of immune gene expression in cattle infected with Brucella abortus.Scientific reports · 2026Article
- Animal Tissue Mineralization: An Overview of Disease Processes, Comparative Pathology, and Diagnostic Approaches.Biomolecules · 2026Review
- To establish an indirect ELISA method for the detection of human brucellosis based on signal peptide-truncated recombinant Cu/Zn SOD and its preliminary clinical verification.Frontiers in cellular and infection microbiology · 2026Article
- Integrating epidemiology with genomic tracing to uncover concealed transmission networks in a brucellosis outbreak, Shandong, China.Frontiers in cellular and infection microbiology · 2026Article
- Blood culture positivity and its clinical determinants among hospitalized male patients with newly diagnosed, laboratory-confirmed brucellosis: a hospital-based retrospective study.Frontiers in microbiology · 2026Article
- Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellae are Gram-negative, small rods infecting mammals and capable of causing disease called brucellosis. The infection results in abortion and sterility in domestic animals (sheeps, pigs, rams etc). Especially dangerous for humans are: Brucella melitensis, Brucella suis, Brucella abortus, and Brucella canis that trigger unspecific symptoms (flu-like manifestation). Brucella rods are introduced via host cells, by inhalation, skin abrasions, ingestion or mucosal membranes. The most important feature of Brucella is the ability to survive and multiply within both phagocytic and non-phagocytic cells. Brucella does not produce classical virulence factors: exotoxin, cytolisins, exoenzymes, plasmids, fimbria, and drug resistant forms. Major virulence factors are: lipopolysaccharide (LPS), T4SS secretion system and BvrR/BvrS system, which allow interaction with host cell surface, formation of an early, late BCV (Brucella Containing Vacuole) and interaction with endoplasmic reticulum (ER) when the bacteria multiply. The treatment of brucellosis is based on two-drug therapy, the most common combinations of antibiotics are: doxycycline with rifampicin or fluoroquinolones with rifampicin. Currently, also other methods are used to disrupt Brucella intracellular replication (tauroursodeoxycholic acid or ginseng saponin fraction A).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.