Evidence map›Paper›PMID 30014843›Full record

ArticleEmerging infectious diseases2018

Toxoplasmosis in Transplant Recipients, Europe, 2010-2014.

Florence Robert-Gangneux, Valeria Meroni, Damien Dupont, Françoise Botterel, José M Aguado Garcia, Marie-Pierre Brenier-Pinchart, Isabelle Accoceberry, Hamdi Akan, Isabella Abbate, Katia Boggian and 25 more

Open access · diamondAbstract readMulticenter Study
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Seroprevalence and risk factors forParasite epidemiology and control · 2025
    Review
  7. Article
  8. Review
  9. Serological Profile of Anti-Tropical medicine and infectious disease · 2025
    Article
  10. Seroepidemiology ofCaspian journal of internal medicine · 2025
    Article
  11. Article
  12. Molecular diagnosis of human toxoplasmosis: the state of the art.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Review
  13. Article
  14. Article
  15. Outcomes of Kidney Transplants From Toxoplasma-Positive Donors: An Organ Procurement and Transplant Network Database Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Article
  16. Frontiers in cellular and infection microbiology · 2024
    Article
  17. Article
  18. Frontiers in cellular and infection microbiology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 2 institutions in 1 country.

Florence Robert-Gangneux
Valeria Meroni
Damien Dupont
Françoise Botterel
José M Aguado Garcia
Marie-Pierre Brenier-Pinchart
Isabelle Accoceberry
Hamdi Akan
Isabella Abbate
Katia Boggian
Fabrizio Bruschi
Jordi Carratalà
Miruna David
Lubos Drgona
Olgica Djurković-Djaković
Maria Carmen Farinas
Francesca Genco
Effrossyni Gkrania-Klotsas
Andreas H Groll
Edward Guy
Cédric Hirzel
Nina Khanna
Özgür Kurt
Lia Monica Junie
Tiziana Lazzarotto
Oscar Len
Nicolas J Mueller
Patricia Munoz
Zoi Dorothea Pana
Emmanuel Roilides
Tijana Stajner
Christian van Delden
Isabelle Villena
Hervé Pelloux
Oriol Manuel
Centre Hospitalier Universitaire de Reims · FRInstitut de Recherche en Santé, Environnement et Travail · FR

Funding

Medical Research Council G0701652
6 · The paper itself

Abstract

Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.

Indexed as

AdultEuropeHematopoietic Stem Cell TransplantationHumansMiddle AgedOrgan TransplantationRetrospective StudiesRisk FactorsToxoplasmosisTransplant Recipientscerebral toxoplasmosischemoprophylaxiscotrimoxazoleEuropehematopoietic stem cell transplantparasitesToxoplasmatoxoplasma infectiontransplantationtransplant recipient

Identifiers

PMID30014843
PMCPMC6056100
OpenAlexW2810033556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.