Evidence map›Paper›PMID 30014839›Full record

ArticleEmerging infectious diseases2018

Case Series of Severe Neurologic Sequelae of Ebola Virus Disease during Epidemic, Sierra Leone.

Patrick J Howlett, Anna R Walder, Durodami R Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N'jai, Colin S Brown, Foday Sahr, Foday Sesay and 9 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  12. Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
  13. Article
  14. Depression in Sub-Saharan Africa.IBRO neuroscience reports · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Patrick J Howlett
Anna R Walder
Durodami R Lisk
Felicity Fitzgerald
Stephen Sevalie
Marta Lado
Abdul N'jai
Colin S Brown
Foday Sahr
Foday Sesay
Jonathon M Read
Paul J Steptoe
Nicholas A V Beare
Reena Dwivedi
Marylou Solbrig
Gibrilla F Deen
Tom Solomon
Malcolm G Semple
Janet T Scott

Funding

Department of Health EME/12/205/28Department of Health IS-HPU-1112-10117Department of Health RP-PG-0108-10048Medical Research Council G116/194Medical Research Council MC_PC_15096Medical Research Council MC_UU_12014/8Wellcome TrustWellcome Trust 107779/Z/15/B
6 · The paper itself

Abstract

We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions. Of brain computed tomography scans of 17 patients, 3 showed cerebral and/or cerebellar atrophy and 2 confirmed strokes. Sixteen patients required mental health followup; psychiatric disorders were diagnosed in 5. The 10 patients who experienced greatest disability had co-existing physical and mental health conditions. EVD survivors may have ongoing central and peripheral nervous system disorders, including previously unrecognized migraine headaches and stroke.

Indexed as

EpidemicsAdultCohort StudiesFemaleHemorrhagic Fever, EbolaHumansMaleMigraine DisordersPeripheral Nervous System DiseasesSierra LeoneStrokeYoung Adult34MH34 Military Hospital34th Military HospitalchoriomeningioencephalitisEbolaFreetownmeningitismeningoencephalitismigraineMilitary Hospital 34neurologicophthalmicpsychiatricSierra Leoneviral sequelaevirusesWest Africa

Identifiers

PMID30014839
PMCPMC6056101
OpenAlexW2840219976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.