Evidence map›Paper›PMID 30014529›Full record

ReviewChemistry (Weinheim an der Bergstrasse, Germany)2019

Molecular Probes for Imaging Fibrosis and Fibrogenesis.

Pauline Désogère, Sydney B Montesi, Peter Caravan

Abstract readReview
In one paragraph

Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
  4. Review
  5. Article
  6. Article
  7. Noninvasive Quantification of Radiation-Induced Lung Injury Using a Targeted Molecular Imaging Probe.International journal of radiation oncology, biology, physics · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Radiolabeled GPVI-Fc for PET Imaging of Multiple Extracellular Matrix Fibers: A New Look into Pulmonary Fibrosis Progression.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Biodistribution, Dosimetry, and Pharmacokinetics ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  14. Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. The Latest Advances in Imaging Crosstalk Between the Immune System and Fibrosis in Cardiovascular Disease.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pauline DésogèreThe Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0001-8620-4108
Sydney B MontesiDivision of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, 02114, USA.
Peter CaravanThe Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0002-3179-6537

Funding

Stable, High Relaxivity MRI Contrast AgentsR01EB009062 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2009 to 2017
$4.9M
PET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3M
Molecular Imaging of Renal FibrogenesisU01DK104302 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2014 to 2019
$2.1M
PET Imaging of Pulmonary FibrosisR01HL116315 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2012 to 2014
$1.3M
National Heart, Lung, and Blood Institute HL116315National Heart, Lung, and Blood Institute HL131907National Institute of Biomedical Imaging and Bioengineering EB009062National Institute of Diabetes and Digestive and Kidney Diseases DK104302NHLBI NIH HHS R01 HL116315NHLBI NIH HHS R01 HL131907NIBIB NIH HHS R01 EB009062NIDDK NIH HHS U01 DK104302
6 · The paper itself

Abstract

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a common result of chronic tissue injury. Advances in the clinical management of fibrotic diseases have been hampered by the low sensitivity and specificity of noninvasive early diagnostic options, lack of surrogate end points for use in clinical trials, and a paucity of noninvasive tools to assess fibrotic disease activity longitudinally. Hence, the development of new methods to image fibrosis and fibrogenesis is a large unmet clinical need. Herein, an overview of recent and selected molecular probes for imaging of fibrosis and fibrogenesis by magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography is provided.

Indexed as

AnimalsFibrosisHumansIntegrinsMagnetic Resonance ImagingMatrix MetalloproteinasesMolecular ProbesPositron-Emission TomographyPulmonary FibrosisTomography, Emission-Computed, Single-PhotonIntegrinsMatrix MetalloproteinasesMolecular Probescollagenfibrogenesisfibrosisimaging agentsmedicinal chemistry

Identifiers

PMID30014529
PMCPMC6542638

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.