ArticleAnnals of neurology2018
Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS.Neurology(R) neuroimmunology & neuroinflammation · 2021Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- Trial
- Plasma urate concentrations and possible REM sleep behavior disorder.Annals of clinical and translational neurology · 2019Trial
- Trial
- Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Association between gout, hyperuricaemia and Parkinson's disease risk: a cohort study in western Sweden (2001-2017).Rheumatology advances in practice · 2025Article
- Uric acid and alterations of purine recycling disorders in Parkinson's disease: a cross-sectional study.NPJ Parkinson's disease · 2024Article
- Consumption of milk and other dairy products and incidence of Parkinson's disease: a prospective cohort study in French women.European journal of epidemiology · 2024Article
- Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024Review
- Serum urate levels and neurodegenerative outcomes: a prospective cohort study and mendelian randomization analysis of the UK Biobank.Alzheimer's research & therapy · 2024Article
- Review
- A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism.Arthritis research & therapy · 2023Article
- Longitudinal follow-up study of the association with gout and Alzheimer's disease and Parkinson's disease in Korea.Scientific reports · 2023Article
- Uric Acid in Parkinson's Disease: What Is the Connection?Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Systematic review of Mendelian randomization studies on Parkinson's disease.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2022Article
- Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with depressive symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- The Promise of Mendelian Randomization in Parkinson's Disease: Has the Smoke Cleared Yet for Smoking and Parkinson's Disease Risk?Journal of Parkinson's disease · 2022Article
- Hyperuricemia, Gout, and the Brain-an Update.Current rheumatology reports · 2021Review
- Genetically predicted serum urate levels have no causal role on depression or other psychiatric disorders.Clinical rheumatology · 2021Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveObservational studies have shown that increased plasma urate is associated with lower risk of Parkinson's disease (PD), but these studies were not designed to test causality. If a causal relationship exists, then modulating plasma urate levels could be a potential preventive avenue for PD. We used a large two-sample Mendelian randomization (MR) design to assess for a causal relationship between plasma urate and PD risk.
methodsWe used a genetic instrument consisting of 31 independent loci for plasma urate on a case-control genome-wide association study data set, which included 13,708 PD cases and 95,282 controls. Individual effect estimates for each SNP were combined using the inverse-variance weighted (IVW) method. Two additional methods, MR-Egger and a penalized weighted median (PWM)-based approach, were used to assess potential bias attributed to pleiotropy or invalid instruments.
resultsWe found no evidence for a causal relationship between urate and PD, with an effect estimate from the IVW method of odds ratio (OR) 1.03 (95% confidence interval [CI], 0.88-1.20) per 1-standard-deviation increase in plasma urate levels. MR Egger and PWM analyses yielded similar estimates (OR, 0.99 [95% CI, 0.83-1.17] and 0.99 [95% CI, 0.86-1.14], respectively).
interpretationWe did not find evidence for a linear causal protective effect by urate on PD risk. The associations observed in previous observational studies may be, in part, attributed to confounding or reverse causality. In the context of the present findings, strategies to elevate circulating urate levels may not reduce overall PD risk. Ann Neurol 2018;84:191-199.
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