ReviewDiabetes therapy : research, treatment and education of diabetes and related disorders2018
A Systematic Review of Ultrasound-Detected Lipohypertrophy in Insulin-Exposed People with Diabetes.
Review in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prevalence of insulin injection-induced lipohypertrophy detected by ultrasound: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- The Distinct Ultrasound Characteristics and Prognostic Features of Insulin-Induced Lipohypertrophy: A Systematic Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- A tension offloading patch mitigates dermal fibrosis induced by pro-fibrotic skin injections.Research square · 2024Article
- Efficacy of Sound Touch Elastography in Assessing Subcutaneous Lipohypertrophy from Insulin Injections.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Addressing Insulin Injection Technique: A Follow-up Study of Canadian Patients with Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
- New ex vivo method to objectively assess insulin spatial subcutaneous dispersion through time during pump basal-rate based administration.Scientific reports · 2023Article
- A Hypothesis on the Progression of Insulin-Induced Lipohypertrophy: An Integrated Result of High-Frequency Ultrasound Imaging and Blood Glucose Control of Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Insulin-related lipohypertrophy: ultrasound characteristics, risk factors, and impact of glucose fluctuations.Endocrine · 2022Article
- Insulin-induced Lipohypertrophy in Patients with Type 1 Diabetes Mellitus Treated with an Insulin Pump.International journal of endocrinology · 2022Article
- Lipohypertrophy prevalence and its associated risk factors in insulin-treated patients with type 2 diabetes in North Borneo, Malaysia.Belitung nursing journal · 2022Article
- Characteristics and morphology of lipohypertrophic lesions in adults with type 1 diabetes with ultrasound screening: an exploratory observational study.BMJ open diabetes research & care · 2021Observational
- Leveraging Mechanical Forces to Target Insulin Injection-Induced Lipohypertrophy and Fibrosis.Diabetes spectrum : a publication of the American Diabetes Association · 2021Article
- A Systematic Survey of Physicians' Insights Into Lipohypertrophy.Frontiers in public health · 2021Article
- Insulin-Induced Skin Lipohypertrophy in Type 2 Diabetes: a Multicenter Regional Survey in Southern Italy.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLipohypertrophy (LH) is a common complication occurring in diabetes individuals. The most common methods used include palpation, visual examination and/or ultrasound (US). To date, there is limited information on the detection sensitivity among the different techniques used to identify LH. This systematic review aimed to identify studies that examined insulin-related LH using US detection to identify the prevalence, characteristics and morphology of LH, and to compare US and clinical palpation methods for detecting LH.
methodsThree electronic databases were systematically searched for studies detecting LH using US in insulin users. Articles were screened for eligibility and included studies were appraised using quality assessment tools. The quality of the evidence was evaluated using Grading of Recommendations Assessment, Development and Evaluation, and the extracted data was synthesised narratively.
resultsSixteen articles were included in the review providing data on 1722 patients. The prevalence of LH prevalence varied from 14.5% to 88% (median 56.6%). Identified risk factors for the development of included insulin injection behaviour such as a lack of injection site rotation and social factors such as low education level. Four studies compared LH detection by US to palpation, providing inconsistent results. One study showed that palpation detected 64% more LH, whilst two studies demonstrated that US identified 50% more sites and extended areas of LH (additional ~ 5 cm
conclusionThe evidence highlights a lack of congruence in results pertaining to the detection sensitivity of US and palpation for LH sites. More research with robust study design is needed to verify whether clinically palpation is sufficient to detect LH, or whether US would increase the precision of LH assessment to help address this common clinically significant problem.
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Registered trials
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