ArticleJournal of neurology2018
Step length predicts executive dysfunction in Parkinson's disease: a 3-year prospective study.
Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The Role of Deep Learning and Gait Analysis in Parkinson's Disease: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- A Double-Blind, Randomized, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Trial
- Development of a Strategy to Predict and Detect Falls Using Wearable Sensors.Journal of medical systems · 2019Trial
- Does cognition affect supervised and unsupervised mobility differently in people with Parkinson's disease? A cross-sectional study.Journal of neuroengineering and rehabilitation · 2026Article
- Dancing through time: Cognitive changes over six years of community dance in Parkinson's disease.Journal of Alzheimer's disease : JAD · 2026Observational
- Cognitive function is associated with the progression of non-tremor motor symptoms in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Examining the Influence of Task Complexity on Dual-Task Performance in Parkinson's Disease and Healthy Older Adults.Neuro-degenerative diseases · 2026Article
- Effects of virtual reality on spatiotemporal gait parameters and freezing of gait in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Differential gait features across Parkinson's disease clinical subtypes.Clinical biomechanics (Bristol, Avon) · 2025Article
- Dual-task-related gait patterns as possible marker of precocious and subclinical cognitive alterations in Parkinson disease.Scientific reports · 2025Article
- Biomechanics Parameters of Gait Analysis to Characterize Parkinson's Disease: A Scoping Review.Sensors (Basel, Switzerland) · 2025Article
- Gait characteristics and factors associated with fall risk in patients with dementia with Lewy bodies.Frontiers in neurology · 2025Article
- Longitudinal associations between physical performance and cognition in individuals with Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Investigating underlying brain structures and influence of mild and subjective cognitive impairment on dual-task performance in people with Parkinson's disease.Scientific reports · 2024Article
- Visual feedback improves propulsive force generation during treadmill walking in people with Parkinson disease.Journal of biomechanics · 2024Article
- Cognitive-motor dual-task interference in Alzheimer's disease, Parkinson's disease, and prodromal neurodegeneration: A scoping review.Gait & posture · 2023Article
- Predicting the fatigue in Parkinson's disease using inertial sensor gait data and clinical characteristics.Frontiers in neurology · 2023Article
- Interplay between gait and neuropsychiatric symptoms in Parkinson's Disease.European journal of translational myology · 2022Article
- Machine Learning Approach to Support the Detection of Parkinson's Disease in IMU-Based Gait Analysis.Sensors (Basel, Switzerland) · 2022Article
- Machine learning can predict mild cognitive impairment in Parkinson's disease.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognition and gait appear to be closely related. The chronological interplay between cognitive decline and gait dysfunction is not fully understood. The aim of the present prospective study is investigating whether the dysfunction of specific gait parameters, during specific task and medication conditions, may predict subsequent cognitive impairment in Parkinson's disease (PD). We evaluated cognition and gait in 39 Parkinsonian patients at an initial assessment and after 3 years. Cognitive performance was evaluated with a neuropsychological battery designed to assess memory, executive/attention, and visuospatial domains. Gait was investigated using a gait analysis system during both the off and on states in the following conditions: (1) normal gait; (2) motor dual task; and (3) cognitive dual task. We used regression models to determine whether gait predicts subsequent cognitive dysfunction. Overall, the cognitive test scores were stable over time with the exception of the executive/attention scores, whereas all gait parameters declined. The step length during the cognitive dual task during the on state at the initial evaluation was the only significant predictor of executive/attention domain dysfunction at follow up. The results were confirmed when executive/attention dysfunction at the initial assessment evaluation was included in the regression model as a covariate. Our longitudinal study offers additional insight into the progression of gait dysfunction, and its chronological relationship with cognitive dysfunction in PD patients. In particular, the present study indicates that step length during a cognitive task when on medication is an independent predictor of future executive/attention decline.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.