Evidence map›Paper›PMID 30014227›Full record

Observational studyInternational journal of hematology2018

Comparison of HHV-6 DNA detection in plasma and whole blood in allogeneic hematopoietic stem cell transplant recipients: frequent false-positive results for active HHV-6 infection using whole blood samples.

Kuniko Takano, Masao Ogata, Rie Kawano, Takako Satou, Yuko Nashimoto, Kuniaki Shirao

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kuniko TakanoDepartment of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.
Masao OgataDepartment of Hematology, Oita University Hospital, Hasama-machi, Yufu, Oita, 879-5593, Japan. mogata@oita-u.ac.jp.ORCID http://orcid.org/0000-0002-4896-5878
Rie KawanoDepartment of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.
Takako SatouDepartment of Clinical Laboratory, Kouseiren Tsurumi Hospital, Oita, Japan.
Yuko NashimotoDepartment of Hematology, Kumamoto Central Hospital, Kumamoto, Japan.
Kuniaki ShiraoDepartment of Medical Oncology and Hematology, Oita University Faculty of Medicine, Oita, Japan.

Funding

Grant-in Aid for Scientific Research 17K09090
6 · The paper itself

Abstract

In this prospective observational study, we compared the human herpesvirus-6 (HHV-6) DNA load in serially collected paired plasma and whole blood (WB) samples from allogeneic hematopoietic stem cell transplantation (HSCT) recipients. A total of 721 paired samples were collected from 68 recipients. The positive rate for HHV-6 DNA was 9.7 and 35.0% in plasma and WB samples, respectively (P < 0.001). The correlation of HHV-6 DNA load between plasma and WB was poor (R

Indexed as

Hematopoietic Stem Cell TransplantationHerpesvirus 6, HumanAdolescentAdultAllograftsDNA, ViralFalse Positive ReactionsFemaleHematologic NeoplasmsHumansMaleMiddle AgedPolymerase Chain ReactionProspective StudiesRoseolovirus InfectionsDNA, ViralAllogeneic hematopoietic stem cell transplantHuman herpesvirus-6mRNAPlasmaWhole blood

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.