ArticleFaraday discussions2018
Single-file transport of water through membrane channels.
Article in Faraday discussions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 81 citations in OpenAlex.
- Cysteine-mediated structural stabilization of the tetrameric GlpF.European biophysics journal : EBJ · 2026Article
- Application of the Transition State Theory in the Study of the Osmotic Permeabilities of AQP7, AQP10 and GlpF.Membranes · 2025Article
- Water Migration through Enzyme Tunnels Is Sensitive to the Choice of Explicit Water Model.Journal of chemical information and modeling · 2025Article
- Water will Find Its Way: Transport through Narrow Tunnels in Hydrolases.Journal of chemical information and modeling · 2024Article
- A hard sphere model for single-file water transport across biological membranes.The European physical journal. E, Soft matter · 2024Article
- Mechanosensitive aquaporins.Biophysical reviews · 2023Review
- Entropic barrier of water permeation through single-file channels.Communications chemistry · 2023Article
- Anomalous ionic transport in tunable angstrom-size water films on silica.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Tutorial for Stopped-Flow Water Flux Measurements: Why a Report about "Ultrafast Water Permeation through Nanochannels with a Densely Fluorous Interior Surface" Is Flawed.Biomolecules · 2023Article
- Honey, I shrunk the extracellular space: Measurements and mechanisms of astrocyte swelling.Glia · 2022Review
- Multiple pore lining residues modulate water permeability of GlpF.Protein science : a publication of the Protein Society · 2022Article
- Molecular-Level Control over Ionic Conduction and Ionic Current Direction by Designing Macrocycle-Based Ionomers.JACS Au · 2022Article
- Experimental and conceptual approaches to root water transport.Plant and soil · 2022Review
- ScatteringNanoscale advances · 2021Article
- An update on passive transport in and out of plant cells.Plant physiology · 2021Review
- The energetic barrier to single-file water flow through narrow channels.Biophysical reviews · 2021Review
- Translational Biophysics - 20Biophysical reviews · 2021Article
- Biophysical Reviews' "Meet the Councilor Series"-a profile of Peter Pohl.Biophysical reviews · 2021Article
- Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI.European radiology experimental · 2021Article
- Native-like membrane models of E. coli polar lipid extract shed light on the importance of lipid composition complexity.BMC biology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water at interfaces governs many processes on the molecular scale from electrochemical and enzymatic reactions to protein folding. Here we focus on water transport through proteinaceous pores that are so narrow that the water molecules cannot overtake each other in the pore. After a short introduction into the single-file transport theory, we analyze experiments in which the unitary water permeability, pf, of water channel proteins (aquaporins, AQPs), potassium channels (KcsA), and antibiotics (gramicidin-A derivatives) has been obtained. A short outline of the underlying methods (scanning electrochemical microscopy, fluorescence correlation spectroscopy, measurements of vesicle light scattering) is also provided. We conclude that pf increases exponentially with a decreasing number NH of hydrogen bond donating or accepting residues in the channel wall. The variance in NH is responsible for a more than hundredfold change in pf. The dehydration penalty at the channel mouth has a smaller effect on pf. The intricate link between pf and the Gibbs activation energy barrier, ΔG‡t, for water flow suggests that conformational transitions of water channels act as a third determinant of pf.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.