Evidence map›Paper›PMID 30014015›Full record

ArticlePractical laboratory medicine2018

Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI.

Camille Chenevier-Gobeaux, Louis Deweerdt, Anne-Valérie Cantero, Bertrand Renaud, Bruno Desmaizières, Sandrine Charpentier, Aline Leroy, Emmanuelle Adelaïde, Delphine Collin-Chavagnac, Eric Bonnefoy-Cudraz and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Practical laboratory medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 15 institutions in 1 country.

Camille Chenevier-GobeauxDepartment of Automated Biological Diagnosis, Cochin Hospital, Hopitaux Universitaires Paris Centre (HUPC), Assistance Publique des Hôpitaux de Paris (APHP), 27 rue du Faubourg Saint-Jacques, 75679 Paris cedex 14, France.
Louis DeweerdtLaboratoire de Biologie Médicale Groupe Biologic, Paray Le Monial, Labco, France.
Anne-Valérie CanteroLaboratoire de Biochimie, CHU Toulouse Rangueil, Toulouse, France.
Bertrand RenaudEmergency Department, Cochin Hospital, Hopitaux Universitaires Paris Centre (HUPC), Assistance Publique des Hôpitaux de Paris (APHP), France.
Bruno DesmaizièresEmergency Department, CH Paray Le Monial, Paray Le Monial, France.
Sandrine CharpentierEmergency Department, CHU Toulouse Rangueil, Toulouse, France.
Aline LeroyLaboratoire de Biologie Médicale, Centre Hospitalier de Bourg-en-Bresse, Bourg-en-Bresse, France.
Emmanuelle AdelaïdeEmergency Department, Centre Hospitalier de Bourg-en-Bresse, Bourg-en-Bresse, France.
Delphine Collin-ChavagnacGroupement Hospitalier Sud Centre de Biologie et de Pathologie Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, France.
Eric Bonnefoy-CudrazCardiology Department, Hospices Civils de Lyon, Lyon, France.
Laurence EstepaLaboratoire de Biologie, Hôpital de Blois, Blois, France.
Akli ChekrouneEmergency Department, Hôpital de Blois, Blois, France.
Sylvie BascoLaboratoire de Biologie Médicale, Centre Hospitalier Henri Duffaut, Avignon, France.
Stéphane AndrieuCardiology Department, Centre Hospitalier Henri Duffaut, Avignon, France.
Stéphane BourgeoisEmergency Department, Centre Hospitalier Henri Duffaut, Avignon, France.
Marie-Agnès CostaLaboratoire de Biochimie, Centre Hospitalier de Limoges, Limoges, France.
Christine VallejoEmergency Department, Centre Hospitalier de Limoges, Limoges, France.
Tiphaine RobertLaboratoire de Biochimie, Hôpital Bichat-Claude Bernard, Hôpitaux Universitaires Paris Nord Val de Seine, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Siham OuahabiLaboratoire de Biochimie et Hormonologie, Hôpital Tenon, Hôpitaux Universitaires Est Parisien, GRC-UPMC BIOSFAST Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Bruno BaudinLaboratoire de Biochimie, Hôpital Saint-Antoine, Hôpitaux Universitaires Est Parisien, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Benedicte Beneteau-BurnatLaboratoire de Biochimie, Hôpital Saint-Antoine, Hôpitaux Universitaires Est Parisien, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Anne-Marie Gorce-DupuyLaboratoire de Biochimie et Hormonologie, Hôpital Lapeyronie, Montpellier, France.
Patrick RayEmergency Department, Hôpital Tenon, Hôpitaux Universitaires Est Parisien, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Claire GastEmergency Department, Hôpital Tenon, Hôpitaux Universitaires Est Parisien, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Monique DehouxLaboratoire de Biochimie, Hôpital Bichat-Claude Bernard, Hôpitaux Universitaires Paris Nord Val de Seine, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Guillaume LefèvreLaboratoire de Biochimie et Hormonologie, Hôpital Tenon, Hôpitaux Universitaires Est Parisien, GRC-UPMC BIOSFAST Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.
Troponins Working Group of the Société Française de Biologie Clinique (SFBC), in collaboration with the Société Française de Médecine d′Urgence (SFMU) and the Société Française de Cardiologie (SFC)
Centre Hospitalier Universitaire Henri-Mondor · FRCentre Hospitalier Universitaire de Limoges · FRHôpital Rangueil · FRHôpital Saint-Antoine · FRSorbonne Université · FRGroupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale · FRHôpital Bichat-Claude-Bernard · FRHôpital Cochin · FRHôpital Lapeyronie · FRHôpital Lyon Sud · FRHôpital Tenon · FRHôpitaux Universitaires Paris-Ouest · FRHospices Civils de Lyon · FRTechnologie Médicale (France) · FRUniversité Claude Bernard Lyon 1 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to compare the use of nine different cardiac troponin (cTn) assays (2 cTnT and 7 cTnI) for the diagnosis of NSTEMI in a single multi-centre population. DESIGN AND

methodsOne hundred and fifty-eight patients were included (mean age 60 years, SD 17 years), including 23 patients (14%) with NSTEMI.

resultsThe analytical comparison highlighted a large heterogeneity of cTn assays, as reflected by percentages of patients with detectable cTn, correlation coefficients, Passing-Bablok comparisons and concordance coefficients. Correlations within cTnI assays were good and correlation within cTnT assays was excellent. Diagnostic performances demonstrated that each cTn assay has specific threshold values. Furthermore, some assays (HS-cTnI and T, cTnI-Pathfast and cTnI-Centaur) indicated high sensitivity and negative predictive value using the limit of detection (LoD) diagnostic strategy. For the latter assays, a significant increase in specificity was found when using the 99th percentile or the H0-H3 strategies, in comparison to the LoD strategy. When applying the European Society of Cardiology H0-H3 algorithm, comparable diagnostic performances were obtained.

conclusionAll 9 cTn assays indicated overall good diagnostic performances for the diagnosis of NSTEMI in emergency departments when the recommended algorithm based on the variation of cTn value between two measurements at admission and 3 h later was used.

Indexed as

Analytical evaluationCardiac troponinChest painEmergency departmentHigh-sensitivity assayNSTEMI

Identifiers

PMID30014015
PMCPMC6045566
OpenAlexW2791430227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.