Evidence map›Paper›PMID 30013986›Full record

ArticleBioMed research international2018

Localization of Glucose Transporter 10 to Hair Cells' Cuticular Plate in the Mouse Inner Ear.

Bei Chen, Yunfeng Wang, Manying Geng, Xi Lin, Wenxue Tang

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Bei ChenDepartment of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Yunfeng WangDepartment of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Manying GengDepartments of Otolaryngology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.
Xi LinDepartments of Otolaryngology and Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-1345-8374
Wenxue TangDepartment of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China.ORCID 0000-0001-8087-0900
Emory University · USEye & ENT Hospital of Fudan University · CNFirst Affiliated Hospital of Zhengzhou University · CNSecond Affiliated Hospital of Zhengzhou University · CNZhengzhou University · CN

Funding

Role of connexins in cochlear functionsR01DC006483 · NIDCD · EMORY UNIVERSITY · PI LIN, XI · 2006 to 2015
$3.4M
Gene Therapy for Treating Human Genetic Deafness Tested in Animal ModelsR01DC014496 · NIDCD · EMORY UNIVERSITY · PI ZHENG, JAMES Q · 2016 to 2020
$2.4M
MOLECULAR MECHANISMS OF THE COCHLEAR EFFERENT FUNCTIONSR01DC004709 · NIDCD · HOUSE EAR INSTITUTE · PI LIN, XI · 2001 to 2005
$1.8M
Restoration of hearing in connexin mutant miceR21DC008672 · NIDCD · EMORY UNIVERSITY · PI TANG, WENXUE · 2007 to 2008
$418k
NIDCD NIH HHS R01 DC004709NIDCD NIH HHS R01 DC006483NIDCD NIH HHS R01 DC014496NIDCD NIH HHS R21 DC008672
6 · The paper itself

Abstract

This study aimed to investigate the localization pattern of glucose transporters (Gluts) in mouse cochlea. Genome-wide gene expression analysis using CodeLink™ bioarrays indicated that Glut1 and Glut10 were highly expressed (~10-fold) in mouse cochlea compared with the other members of glucose transporters (Glut2-6, Glut8, and Glut9). Semiquantitative RT-PCR and western blotting confirmed that Glut10 expression in mouse cochlea was high throughout the embryogenesis and postnatal development. Immunofluorescent staining showed that Glut10 protein was localized in the cuticular plate of the outer and inner cochlear hair cells and in the ampullary crest of the vestibular system. Based on these results, it was supposed that Glut10 may contribute to glucose transport from the endolymph to the hair cells across the cuticular plate.

Indexed as

AnimalsCochleaEar, InnerGlucose Transport Proteins, FacilitativeHair Cells, AuditoryHair Cells, Auditory, InnerMaleMiceGlucose Transport Proteins, Facilitative

Identifiers

PMID30013986
PMCPMC6022331
OpenAlexW2808267844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.