ArticleFrontiers in veterinary science2018
Zinc Nanoparticles Enhance Brain Connectivity in the Canine Olfactory Network: Evidence From an fMRI Study in Unrestrained Awake Dogs.
Article in Frontiers in veterinary science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Non-invasive canine electroencephalography (EEG): a systematic review.BMC veterinary research · 2025Pooled it
- The Role of Olfaction in Dogs: Evolution, Biology, and Human-Oriented Work.Animals : an open access journal from MDPI · 2026Review
- Synthetic Cadaver Odorants and the Sulfur Gap: Linking Chemistry and Canine Olfaction in Human Remains Detection.Molecules (Basel, Switzerland) · 2025Review
- Dogs' olfactory resting-state functional connectivity is modulated by age and brain shape.Scientific reports · 2025Article
- Domestic dogs as a comparative model for social neuroscience: Advances and challenges.Neuroscience and biobehavioral reviews · 2024Review
- Two Separate Brain Networks for Predicting Trainability and Tracking Training-Related Plasticity in Working Dogs.Animals : an open access journal from MDPI · 2024Article
- The Role of Endogenous Metal Nanoparticles in Biological Systems.Biomolecules · 2021Review
- Canine Olfaction: Physiology, Behavior, and Possibilities for Practical Applications.Animals : an open access journal from MDPI · 2021Review
- Human-dog relationships as a working framework for exploring human-robot attachment: a multidisciplinary review.Animal cognition · 2021Review
- Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant.Scientific reports · 2020Article
- Multi-Level Clustering of Dynamic Directional Brain Network Patterns and Their Behavioral Relevance.Frontiers in neuroscience · 2019Article
- Separate brain areas for processing human and dog faces as revealed by awake fMRI in dogs (Canis familiaris).Learning & behavior · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior functional Magnetic Resonance Imaging (fMRI) studies have indicated increased neural activation when zinc nanoparticles are added to odorants in canines. Here we demonstrate that zinc nanoparticles up-regulate directional brain connectivity in parts of the canine olfactory network. This provides an explanation for previously reported enhancement in the odor detection capability of the dogs in the presence of zinc nanoparticles. In this study, we obtained fMRI data from awake and unrestrained dogs while they were being exposed to odorants with and without zinc nanoparticles, zinc nanoparticles suspended in water vapor, as well as just water vapor alone. We obtained directional connectivity between the brain regions of the olfactory network that were significantly stronger for the condition of odorant + zinc nanoparticles compared to just odorants, water vapor + zinc nanoparticles and water vapor alone. We observed significant strengthening of the paths of the canine olfactory network in the presence of zinc nanoparticles. This result indicates that zinc nanoparticles could potentially be used to increase canine detection capabilities in the environments of very low concentrations of the odorants, which would have otherwise been undetected.
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Registered trials
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