ArticleNeuroImage. Clinical2018
Functional and structural brain networks in posterior cortical atrophy: A two-centre multiparametric MRI study.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Disrupted brain topological network and its association with clinical features in posterior cortical atrophy.Brain communications · 2026Article
- Functional network contributions to longitudinal tau spread in Posterior Cortical Atrophy.NPJ dementia · 2026Article
- Posterior Cortical Atrophy: Altered Language Processing System Connectivity and Its Implications on Language Comprehension and Production.Brain sciences · 2025Article
- The Heterogeneity of Reading and Spelling Deficits in Posterior Cortical Atrophy.Brain sciences · 2025Article
- Posterior cortical atrophy: reorganization of the dorsal attention network and its implications on volume loss and clinical performance.Journal of neurology · 2025Article
- Neural mechanisms of disease pathology and cognition in young-onset Alzheimer's disease variants.Journal of Alzheimer's disease : JAD · 2025Article
- Greater baseline cortical atrophy in the dorsal attention network predicts faster clinical decline in Posterior Cortical Atrophy.Alzheimer's research & therapy · 2024Article
- Greater baseline cortical atrophy in the dorsal attention network predicts faster clinical decline in Posterior Cortical Atrophy.medRxiv : the preprint server for health sciences · 2024Article
- Longitudinal default mode sub-networks in the language and visual variants of Alzheimer's disease.Brain communications · 2024Article
- "Quality over quantity:" smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor.Frontiers in neurology · 2024Article
- Anterior dorsal attention network tau drives visual attention deficits in posterior cortical atrophy.Brain : a journal of neurology · 2023Article
- Diffusivity Changes in Posterior Cortical Atrophy and Logopenic Progressive Aphasia: A Longitudinal Diffusion Tensor Imaging Study.Journal of Alzheimer's disease : JAD · 2023Article
- Posterior white matter integrity and self-reported posterior cortical symptoms using the Colorado Posterior Cortical Questionnaire.Frontiers in neurology · 2023Article
- Article
- Imaging Clinical Subtypes and Associated Brain Networks in Alzheimer's Disease.Brain sciences · 2022Review
- Characterizing Differences in Functional Connectivity Between Posterior Cortical Atrophy and Semantic Dementia by Seed-Based Approach.Frontiers in aging neuroscience · 2022Article
- Medial Temporal Atrophy in Posterior Cortical Atrophy and Its Relationship to the Cingulate Island Sign.Journal of Alzheimer's disease : JAD · 2022Article
- Splenial white matter integrity is associated with memory impairments in posterior cortical atrophy.Brain communications · 2021Article
- Benson's Disease or Posterior Cortical Atrophy, Revisited.Journal of Alzheimer's disease : JAD · 2021Review
- Update on posterior cortical atrophy.Current opinion in neurology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study identified structural and functional brain connectivity alterations in two independent samples of patients along the posterior cortical atrophy (PCA) disease course. Twenty-one PCA patients and 44 controls were recruited from two expert centres. Microstructural damage of white matter (WM) tracts was assessed using probabilistic tractography; resting state (RS) functional connectivity of brain networks was explored using a model free approach; grey matter (GM) atrophy was investigated using voxel-based morphometry. Compared with controls, common patterns of damage across PCA patients included: GM atrophy in the occipital-temporal-parietal regions; diffusion tensor (DT) MRI alterations of the corpus callosum and superior (SLF) and inferior longitudinal fasciculi (ILF) bilaterally; and decreased functional connectivity of the occipital gyri within the visual network and the precuneus and posterior cingulum within the default mode network (DMN). In PCA patients with longer disease duration and greater disease severity, WM damage extended to the cingulum and RS functional connectivity alterations spread within the frontal, dorsal attentive and salience networks. In PCA, reduced DMN functional connectivity was associated with SLF and ILF structural alterations. PCA patients showed distributed WM damage. Altered RS functional connectivity extends with disease worsening from occipital to temporo-parietal and frontostriatal regions, and this is likely to occur through WM connections. Future longitudinal studies are needed to establish trajectories of damage spreading in PCA and whether a combined DT MRI/RS functional MRI approach is promising in monitoring the disease progression.
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